RPL15过表达对肝内胆管癌预后的影响:肿瘤侵袭性行为的标志。

IF 2.3 3区 医学 Q2 PATHOLOGY
Wen-Ching Wang, Chien-Jui Huang, Han-Ping Hsu, Yu-Hsuan Kuo, Khaa Hoo Ong, Ding-Ping Sun, Yu-Feng Tian, Chia-Ling Chou, Ti-Chun Chan, Chung-Hsi Hsing, Wan-Shan Li, Hong-Lin He
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引用次数: 0

摘要

背景:核糖体蛋白的过度表达已在多种癌症类型中被发现,并且在细胞增殖和肿瘤发生中起重要作用。对胆管癌表达谱的分析显示,与周围肝脏和胆道组织相比,核糖体蛋白L15 (RPL15)在癌组织中显著上调。因此,我们试图研究RPL15在肝内胆管癌中的作用。方法:采用免疫组化方法检测RPL15在肝内胆管癌组织中的表达。分析RPL15表达水平与临床病理参数的关系,并探讨其在总生存期(OS)、疾病特异性生存期(DSS)、局部无复发生存期(LRFS)和无转移生存期(MeFS)中的预后意义。结果:在182例肝内胆管癌患者中,RPL15高表达与肿瘤晚期(pT)分期(P = 0.005)和高组织学分级(P = 0.018)显著相关。在单因素分析中,RPL15过表达预测更糟糕的DSS (P = 0.0001), LRFS (P)。结论:RPL15过表达被认为是预测肝内胆管癌更糟糕结局的不良预后因素。RPL15可以作为潜在的治疗靶点,帮助开发新的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prognostic impact of RPL15 overexpression in intrahepatic cholangiocarcinoma: a marker of aggressive tumor behavior.

Prognostic impact of RPL15 overexpression in intrahepatic cholangiocarcinoma: a marker of aggressive tumor behavior.

Prognostic impact of RPL15 overexpression in intrahepatic cholangiocarcinoma: a marker of aggressive tumor behavior.

Prognostic impact of RPL15 overexpression in intrahepatic cholangiocarcinoma: a marker of aggressive tumor behavior.

Background: Overexpression of ribosomal proteins has been found in several cancer types and has an important role in cell proliferation and tumorigenesis. Analysis of the expression profiles of cholangiocarcinoma revealed that ribosomal protein L15 (RPL15) was significantly upregulated in cancer tissues compared to surrounding liver and biliary tissues. Thus, we tried to investigate the role of RPL15 in intrahepatic cholangiocarcinoma.

Methods: The expression of RPL15 in intrahepatic cholangiocarcinoma was assessed using immunohistochemistry. The relationships between RPL15 expression levels and clinicopathological parameters were analyzed, along with investigating its prognostic significance in overall survival (OS), disease-specific survival (DSS), local recurrence-free survival (LRFS) and metastasis-free survival (MeFS).

Results: In the cohort comprising 182 patients with intrahepatic cholangiocarcinoma, high expression of RPL15 was significantly associated with advanced tumor (pT) stage (P = 0.005) and high histological grade (P = 0.018). In univariate analyses, overexpression of RPL15 predicted worse DSS (P = 0.0001), LRFS (P < 0.0001) and MeFS (P < 0.0001), but not OS (P = 0.3960). Multivariate analyses revealed that RPL15 overexpression independently predicted worse DSS (P = 0.039), LRFS (P < 0.001) and MeFS (P < 0.001).

Conclusions: Overexpression of RPL15 was identified as an adverse prognostic factor predicting worse outcomes in intrahepatic cholangiocarcinoma. RPL15 could serve as a potential therapeutic target to aid in developing new treatment strategies.

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来源期刊
Diagnostic Pathology
Diagnostic Pathology 医学-病理学
CiteScore
4.60
自引率
0.00%
发文量
93
审稿时长
1 months
期刊介绍: Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).
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