比利时1型糖尿病患者的高死亡率：一项基于人群的研究

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-08-21 DOI:10.1016/j.diabres.2025.112426

Christophe de Meester, Ans Van Ginckel, Irm Vinck, Maria Eyssen, Diego Castanares-Zapatero

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引用次数: 0

摘要

目的：1型糖尿病（T1D）治疗的技术进步有望对死亡率产生有益影响。目的是调查比利时生活和接受治疗的成年T1D患者与普通人群相比的超额死亡率和预期寿命（LE）。方法：纳入2017-2021年糖尿病自我管理多学科护理项目的患者。根据健康和/或药物使用情况确定合并症。结果：共发现144960例患者/年（PY）（2057例死亡）。标准死亡率（95 % CI）为1.21(1.19;1.23)，相当于每1000日元死亡3.2人的超额死亡率。肾功能不全似乎是唯一的合并症与明显的影响，在年轻的年龄组。在20-50岁 岁的T1D患者中，LE导致4 年的寿命损失。结论：尽管我们的分析显示，与以前的研究相比，T1D的超额死亡率显著降低，但仍然显示出适度增加的超额死亡率风险。鉴于糖尿病治疗的不断进步，有必要进行进一步的分析，以重新评估过高的死亡风险，并监测这一积极趋势。

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Excess mortality in type 1 diabetes patients in Belgium: A population based study

Aims

Technological advances in the management of Type 1 diabetes (T1D) are expected to have beneficial effects on the mortality. The aim was to investigate the excess mortality and the life expectancy (LE) of adult patients with T1D living and receiving treatment in Belgium compared with the general population.

Methods

Patients enrolled in the multidisciplinary care programme for the self-management of diabetes mellitus during the years 2017–2021 were included. Comorbidities were identified by proxies based on health and/or medication use.

Results

In total 144 960 patients/year (PY) were identified (2 057 deaths). The standard mortality rate (95 % CI) was 1.21 (1.19;1.23), corresponding to an excess mortality rate of 3.2 deaths per 1 000 PY. Renal insufficiency appeared to be the only comorbidity with a discernible effect on younger age groups. In T1D patients aged 20–50 years, LE results in a loss of 4 years of life.

Conclusions

Although our analysis showed a significantly lower excess mortality rate in T1D compared with older studies, a moderately increased excess risk of mortality is still shown. Given the continuous advances in diabetes treatment, it is important to perform further analyses to reassess the excess risk of mortality and to monitor this positive trend.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.