健康的综合社会决定因素导致抑郁症的不良健康结果:来自两个国家队列的证据。

IF 6.1 2区 医学 Q1 PSYCHIATRY
Xin Qi, Li Liu, Jin Yang, Chuyu Pan, Jingcan Hao, Wenming Wei, Shiqiang Cheng, Yifan Gou, Boyue Zhao, Yan Wen, Bolun Cheng, Feng Zhang
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引用次数: 0

摘要

目的:健康的社会决定因素(SDHs)对各种健康结果和差距产生重大影响。本研究旨在探讨合并sdh与成人抑郁症患者死亡率以及不良健康结局之间的关系。方法:该研究包括来自英国生物银行的48897名抑郁症患者和来自美国国家健康与营养检查调查(NHANES)的7771名抑郁症患者。通过计算基于英国生物银行中14个SDH和美国NHANES中9个SDH的综合SDH评分,参与者通过分位数被分为有利、中等和不利的SDH组。使用Cox回归模型评估联合sdh对两个队列中死亡率(全因、心血管疾病[CVD]和癌症)的影响,以及UK Biobank中CVD、癌症和痴呆的发病率。结果:在完全调整的模型中,与有利SDH组相比,在英国生物银行队列中,不利SDH组的全因死亡率风险比为1.81 (95% CI: 1.60-2.04);在美国NHANES队列中,中度SDH组为1.61 (95% CI: 1.31-1.98),不良SDH组为2.19 (95% CI: 1.78-2.68)。此外,不利的sdh水平较高与心血管疾病和癌症死亡风险增加有关。在疾病发病率方面,在英国生物银行中,它们与心血管疾病和痴呆的高发病率显著相关,但与癌症无关。结论:综合不利的sdh与成人抑郁症患者死亡风险升高和不良健康结果相关,这表明评估sdh的综合影响可以作为预防和管理抑郁症的关键策略,最终有助于减轻疾病负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts.

Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts.

Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts.

Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts.

Aims: Social determinants of health (SDHs) exert a significant influence on various health outcomes and disparities. This study aimed to explore the associations between combined SDHs and mortality, as well as adverse health outcomes among adults with depression.

Methods: The research included 48,897 participants with depression from the UK Biobank and 7,771 from the US National Health and Nutrition Examination Survey (NHANES). By calculating combined SDH scores based on 14 SDHs in the UK Biobank and 9 in the US NHANES, participants were categorized into favourable, medium and unfavourable SDH groups through tertiles. Cox regression models were used to evaluate the impact of combined SDHs on mortality (all-cause, cardiovascular disease [CVD] and cancer) in both cohorts, as well as incidences of CVD, cancer and dementia in the UK Biobank.

Results: In the fully adjusted models, compared to the favourable SDH group, the hazard ratios for all-cause mortality were 1.81 (95% CI: 1.60-2.04) in the unfavourable SDH group in the UK Biobank cohort; 1.61 (95% CI: 1.31-1.98) in the medium SDH group and 2.19 (95% CI: 1.78-2.68) in the unfavourable SDH group in the US NHANES cohort. Moreover, higher levels of unfavourable SDHs were associated with increased mortality risk from CVD and cancer. Regarding disease incidence, they were significantly linked to higher incidences of CVD and dementia but not cancer in the UK Biobank.

Conclusions: Combined unfavourable SDHs were associated with elevated risks of mortality and adverse health outcomes among adults with depression, which suggested that assessing the combined impact of SDHs could serve as a key strategy in preventing and managing depression, ultimately helping to reduce the burden of disease.

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来源期刊
CiteScore
7.80
自引率
1.20%
发文量
121
审稿时长
>12 weeks
期刊介绍: Epidemiology and Psychiatric Sciences is a prestigious international, peer-reviewed journal that has been publishing in Open Access format since 2020. Formerly known as Epidemiologia e Psichiatria Sociale and established in 1992 by Michele Tansella, the journal prioritizes highly relevant and innovative research articles and systematic reviews in the areas of public mental health and policy, mental health services and system research, as well as epidemiological and social psychiatry. Join us in advancing knowledge and understanding in these critical fields.
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