Amarogentin,天然苦萜类化合物:药理潜力、专利和毒性研究进展。

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Sonia Singh, Mahima Varshney, Himanshu Sharma
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引用次数: 0

摘要

苦苣苔素是一种从药用植物獐牙菜中分离得到的环烯醚萜苷类化合物。它以其强大的苦味特征和它所具有的各种药理作用而闻名。特别是在传统和现代医学实践中,这种分子由于其巨大的治疗潜力而引起了相当大的关注。Amarogentin具有广泛的生物作用,其中一些功能包括保肝、抗炎、抗癌、抗糖尿病和抗菌。它所具有的保肝功能是通过增强抗氧化防御系统和减少毒素引起的肝脏损伤来实现的。据信,amarogentin阻断促炎介质(如TNF-α和IL-6)的能力是其抗炎特性的原因。在各种肿瘤模型中,刺激细胞凋亡和减少癌细胞增殖是它显示出有希望的抗癌潜力的另外两种方式。amarogentin的抗糖尿病活性的特点是改变葡萄糖代谢和改善胰岛素敏感性。为了提高amarogentin的治疗效果,需要进一步研究其在人体中的生物利用度和稳定性。尽管事实上它具有广泛的药理优势。有一些配方选择可以改善其药代动力学特征。这些策略的一些例子是纳米颗粒输送系统和衍生化。总的来说,amarogentin作为治疗肝脏疾病、癌症和代谢紊乱的天然治疗剂显示出很大的希望。因此,有必要进一步研究其临床应用和潜在用途的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Amarogentin, Natural Bitter Terpenoids: Research Update with Pharmacological Potential, Patent and Toxicity Aspects.

Amarogentin is a secoiridoid glycoside that was initially isolated from the medicinal plant Swertia chirayita. It is well-known for its formidable bitter characteristics and the varied pharmacological actions it possesses. Especially in both conventional and modern medical practices, this molecule has garnered considerable attention due to its enormous therapeutic potential. Amarogentin possesses a wide range of biological actions, some of which include functions that are hepatoprotective, anti-inflammatory, anti-cancer, anti-diabetic, and antibacterial. The hepatoprotective function it possesses is achieved by enhancing antioxidant defense systems and reducing liver damage caused by toxins. It is believed that the ability of amarogentin to block proinflammatory mediators, such as TNF-α and IL-6, is responsible for its anti-inflammatory properties. The stimulation of apoptosis and the reduction of cancer cell proliferation in various tumor models are two additional ways in which it demonstrates promising anti-cancer potential. The antidiabetic activity of amarogentin is characterized by the modification of glucose metabolism as well as an improvement in insulin sensitivity. To enhance the therapeutic efficacy of amarogentin, further research is needed to investigate its bioavailability and stability in the human body. This is despite the fact that it possesses a wide range of pharmacological advantages. There are formulation options that could improve its pharmacokinetic profile. Some examples of these strategies are nanoparticle delivery systems and derivatization. In general, amarogentin exhibits a great deal of promise as a natural therapeutic agent for the treatment of liver diseases, cancer, and metabolic disorders. Accordingly, there is a need for further research into the mechanisms underlying its clinical applications and potential uses.

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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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