下丘脑轴对焦虑相关过程的影响:考虑其神经相关性的RDoC综述

IF 6.7 2区 医学 Q1 PSYCHIATRY
Current Psychiatry Reports Pub Date : 2025-10-01 Epub Date: 2025-08-30 DOI:10.1007/s11920-025-01633-5
Paula Ariño-Braña, Michal Rafal Zareba, Marcos Ibáñez Montolio, Maya Visser, Maria Picó-Pérez
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引用次数: 0

摘要

回顾目的:通过多维视角,我们使用研究领域标准(RDoC)框架,回顾了有关焦虑相关过程、下丘脑-垂体-肾上腺(HPA)轴功能(特别关注皮质醇)及其神经相关物之间联系的文献。这种方法旨在通过解决这些过程的异质性、多维性和潜在的神经生物学机制来捕捉这些过程的复杂性。最近的发现:在RDoC框架内,皮质醇失调(无论是过度升高还是钝化)与负效价、正效价、认知、社会、觉醒和感觉运动系统的不同过程的中断有关。这些作用与不同的神经基质有关,包括边缘、纹状体和前额叶控制区。不同的过程和神经生物学反应以复杂的双向方式相互作用,理解这些相互依赖关系对于捕捉焦虑相关过程的全部性质至关重要。这些发现强化了采用多维的、基于rdoc的框架的价值,它允许对心理健康有更综合和更机械的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of the HPA Axis on Anxiety-Related Processes: An RDoC Overview Considering Their Neural Correlates.

Purpose of review: Through a multidimensional lens, we review the literature on the link between anxiety-related processes, hypothalamic-pituitary-adrenal (HPA) axis functioning (with a particular focus on cortisol), and their neural correlates, using the Research Domain Criteria (RDoC) framework. This approach aims to capture the complexity of these processes by addressing their heterogeneity, multidimensionality, and underlying neurobiological mechanisms.

Recent findings: Within the RDoC framework, dysregulated cortisol (whether excessively elevated or blunted) has been linked to disruptions in different processes of the negative valence, positive valence, cognitive, social, arousal, and sensorimotor systems. These effects are associated with distinct neural substrates, including limbic, striatal, and prefrontal control areas. Different processes and neurobiological responses interact in complex, bidirectional ways, and understanding these interdependencies is essential for capturing the full nature of anxiety-related processes. These findings reinforce the value of adopting a multidimensional, RDoC-based framework, which allows for a more integrative and mechanistic understanding of mental health.

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来源期刊
CiteScore
11.30
自引率
3.00%
发文量
68
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published research in psychiatry. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by psychiatric disorders. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anxiety, medicopsychiatric disorders, and schizophrenia and other related psychotic disorders. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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