Paula Ariño-Braña, Michal Rafal Zareba, Marcos Ibáñez Montolio, Maya Visser, Maria Picó-Pérez
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Influence of the HPA Axis on Anxiety-Related Processes: An RDoC Overview Considering Their Neural Correlates.
Purpose of review: Through a multidimensional lens, we review the literature on the link between anxiety-related processes, hypothalamic-pituitary-adrenal (HPA) axis functioning (with a particular focus on cortisol), and their neural correlates, using the Research Domain Criteria (RDoC) framework. This approach aims to capture the complexity of these processes by addressing their heterogeneity, multidimensionality, and underlying neurobiological mechanisms.
Recent findings: Within the RDoC framework, dysregulated cortisol (whether excessively elevated or blunted) has been linked to disruptions in different processes of the negative valence, positive valence, cognitive, social, arousal, and sensorimotor systems. These effects are associated with distinct neural substrates, including limbic, striatal, and prefrontal control areas. Different processes and neurobiological responses interact in complex, bidirectional ways, and understanding these interdependencies is essential for capturing the full nature of anxiety-related processes. These findings reinforce the value of adopting a multidimensional, RDoC-based framework, which allows for a more integrative and mechanistic understanding of mental health.
期刊介绍:
This journal aims to review the most important, recently published research in psychiatry. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by psychiatric disorders.
We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anxiety, medicopsychiatric disorders, and schizophrenia and other related psychotic disorders. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.