壳聚糖纳米颗粒对肥胖大鼠的体内和体内肝肾保护作用。

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Tahani Younis Omar, Saja Mohammad Al-Mosaidyyen, Esraa Nasser Mohammed, Nada Alaa Saied, Fatma Alzhraa Ayman, Juliana Kamal Khalil, Abdeljalil Mohamed Al Shawoush, Ayman Saber Mohamed
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引用次数: 0

摘要

肥胖症是一种以身体脂肪过多为特征的普遍健康状况,它显著增加了患慢性病的风险,并已成为一个主要的全球健康问题。黄菊花素是一种具有健康益处的类黄酮,具有有效的抗氧化和抗炎特性。本研究旨在研究壳聚糖金菊素纳米颗粒(chrysin - csnps)对高脂肪饮食(HFD)诱导的雄性大鼠肥胖的影响。方法:先给大鼠高脂饲料4周诱导肥胖,再给药4周。将30只大鼠分为5组(每组6只):对照组(清水,口服)、HFD对照组(清水,口服)、HFD +白蜡素(500 mg/kg,口服)、HFD +壳聚糖- np (60 mg/kg,口服)、HFD +白蜡素- csnps (60 mg/kg,口服)。结果:硅研究表明,菊花素对脂肪质量和肥胖相关(FTO)蛋白的结合能值为-8.8 kcal/mol。此外,Chrysin被鉴定为几种细胞色素P450酶的抑制剂,特别是CYP1A2, CYP2D6和CYP3A4。白蛋白、高密度脂蛋白胆固醇、谷胱甘肽和一氧化氮水平升高,而葡萄糖、丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶、肌酐、尿素、总胆固醇、甘油三酯、丙二醛和一氧化氮水平在Chrysin-CSNPS处理后下降。组织学检查显示肝脏和肾脏结构明显增强。讨论:这些发现表明,菊花素可能潜在地抑制FTO活性,从而有助于减少肥胖相关的表型。选择符合利平斯基标准的化合物进行毒性预测。结论:金菊素- csnps具有降血脂和抗氧化作用,可减轻HFD对肝脏和肾脏的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In Silico and In Vivo Hepatorenal Protective Effect of Chitosan-Loaded Chrysin Nanoparticles in Obese Rats.

Introduction: Obesity, a widespread health condition marked by excessive body fat, markedly elevates the risk of chronic diseases and has emerged as a major global health issue. Chrysin, a flavonoid with promising health benefits, exhibits potent antioxidant and antiinflammatory properties. This study seeks to examine the impact of chitosan chrysin nanoparticles (Chrysin-CSNPS) on obesity induced by a high-fat diet (HFD) in male rats.

Methods: Rats were fed a high-fat diet for 4 weeks to induce obesity, followed by a 4-week treatment period. Thirty rats were allocated into five groups (six rats per group): control (dist. water, orally), HFD control (dist. water, orally), HFD + chrysin (500 mg/kg, orally), HFD + chitosan-NP (60 mg/kg, orally), and HFD + Chrysin-CSNPS (60 mg/kg, orally).

Results: In silico studies revealed that chrysin has a binding energy value of -8.8 kcal/mol to fat mass and obesity-associated (FTO) protein. Also, Chrysin is identified as an inhibitor of several cytochrome P450 enzymes, specifically CYP1A2, CYP2D6, and CYP3A4. Albumin, high-density lipoprotein cholesterol, glutathione, and nitric oxide levels rose, whereas glucose, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatinine, urea, total cholesterol, triglycerides, malondialdehyde, and nitric oxide levels fell upon Chrysin-CSNPS treatment. The histological examination revealed a significant enhancement in the structures of the liver and kidneys.

Discussion: These findings suggest that chrysin could potentially inhibit FTO activity, thereby contributing to a reduction in obesity-related phenotypes. The compound that satisfied Lipinski's criteria was selected for toxicity prediction.

Conclusion: Chrysin-CSNPS have hypolipidemic properties and an antioxidant role, reducing HFD consequences in the liver and kidney.

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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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