hiv相关弥漫性大b细胞淋巴瘤患者外周血淋巴细胞亚群特征及其对治疗效果的影响

IF 1 4区 医学 Q4 IMMUNOLOGY
Huiyu Xiang, Can Lin, Shuang Chen, Yu Peng, Tingting Jiang, Changhai Lin, Qing Xiao, Xiaomei Zhang, Tingting Liu, Nanjun Li, Xinyi Tang, Yakun Zhang, Junxi Liu, Zailin Yang
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引用次数: 0

摘要

外周血淋巴细胞亚群已被证明影响hiv相关弥漫性大b细胞淋巴瘤(HIV-DLBCL)的预后,HIV-DLBCL是一种罕见且高度侵袭性的非霍奇金淋巴瘤,与免疫抑制和异常b细胞增殖有关。为了根据CD4+/CD8+比值、Treg/NK细胞特征等因素进行个体化治疗奠定基础,本研究通过回顾性研究探讨淋巴细胞亚群水平的变化。方法:共纳入51例HIV-DLBCL患者、50例DLBCL患者和42例健康供体(HD)。数据从门诊记录和医院信息管理系统中提取。采用SPSS 27.0软件对数据进行统计分析。结果:各组淋巴细胞亚群差异有统计学意义。与DLBCL患者和HD患者相比,HIVDLBCL患者CD4 + T细胞和调节性T细胞(Treg)计数/百分比降低,但CD8 + T细胞计数和百分比以及Treg百分比增加。年龄分层分析显示,与年轻患者相比,老年HIV-DLBCL患者CD8 + T细胞计数较低,CD3 + T细胞百分比降低,CD56 + CD16 + NK细胞比例升高。讨论:本研究揭示了HIV-DLBCL患者免疫失调的独特模式,其特征是CD4 + T细胞耗竭和CD8 + T细胞扩增,这与以往的研究一致。年龄相关性免疫衰老可能加剧NK细胞比例的增加和t细胞功能的下降,提示老年患者预后较差。然而,淋巴细胞亚群与化疗疗效之间缺乏关联可能反映了标准方案对免疫重建的广泛影响。局限性包括样本量小,缺乏功能性实验,以及未能评估合并感染的影响。未来的研究应该扩大队列并整合多组学数据来验证这些发现。结论:与DLBCL患者相比,HIV-DLBCL患者外周血淋巴细胞亚群有明显的改变,如CD4+ T细胞的绝对计数和百分比下降。这些改变似乎与年龄有关,与先前的抗逆转录病毒治疗没有显著关联。然而,化疗对HIV-DLBCL的治疗效果可能不会受到外周血中CD4+ t细胞绝对计数和百分比较低以及他们之前是否接受过抗逆转录病毒治疗的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Characteristics of Peripheral Blood Lymphocyte Subsets in HIV-related Diffuse Large B-cell Lymphoma Patients and Their Impact on Treatment Efficacy.

Introduction: Peripheral blood lymphocyte subsets have been shown to influence prognosis in HIV-associated Diffuse Large B-Cell Lymphoma (HIV-DLBCL), a rare and highly aggressive form of non-Hodgkin's lymphoma linked to immunosuppression and abnormal B-cell proliferation. To lay the foundation for individualized therapy based on factors such as CD4+/CD8+ ratio and Treg/NK cell characteristics, this retrospective study was conducted to explore the variations in lymphocyte subset levels.

Methods: Overall, 51 HIV-DLBCL patients, 50 DLBCL patients, and 42 Healthy Donors (HD) were enrolled in the study. Data were extracted from outpatient records and the Hospital Information Management System. SPSS 27.0 software was used for statistical analysis of the data.

Results: Significant differences in lymphocyte subsets were observed between groups. HIVDLBCL patients showed decreased CD4⁺ T cell and regulatory T cell (Treg) counts/percentages compared to DLBCL patients and HD, but increased CD8⁺ T cell counts and percentages, as well as Treg percentages. Age-stratified analysis revealed that older HIV-DLBCL patients had lower CD8⁺ T cell counts, reduced CD3⁺ T cell percentages, and elevated CD56⁺CD16⁺ NK cell proportions compared to their younger counterparts.

Discussion: This study revealed a distinct pattern of immune dysregulation in HIV-DLBCL patients, characterized by CD4⁺ T cell depletion and CD8⁺ T cell expansion, which is consistent with previous studies. Age-related immunosenescence may exacerbate the increased proportion of NK cells and the decline in T-cell function, suggesting a poorer prognosis in elderly patients. However, the lack of association between lymphocyte subsets and chemotherapy efficacy may reflect the broad impact of standard regimens on immune reconstitution. Limitations include the small sample size, absence of functional experiments, and failure to assess the influence of coinfections. Future studies should expand the cohort and integrate multi-omics data to validate these findings.

Conclusion: Patients with HIV-DLBCL have distinctive alterations in peripheral blood lymphocyte subsets, such as a decreased absolute count and percentage of CD4+ T cells, in comparison to individuals with DLBCL. These alterations appear age-related and showed no significant association with prior antiretroviral therapy. The therapeutic effect of chemotherapy for HIV-DLBCL, however, might not be impacted by the low absolute count and percentage of CD4+ T-cells in peripheral blood, as well as whether or not they had previously received antiretroviral therapy.

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来源期刊
Current HIV Research
Current HIV Research 医学-病毒学
CiteScore
1.90
自引率
10.00%
发文量
81
审稿时长
6-12 weeks
期刊介绍: Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.
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