他达拉非对勃起功能障碍患者光学相干断层扫描、光学相干断层血管成像和神经节细胞复合物参数的影响。

IF 2 4区 医学 Q3 OPHTHALMOLOGY
Current Eye Research Pub Date : 2025-10-01 Epub Date: 2025-08-29 DOI:10.1080/02713683.2025.2523913
Mohadeseh Feizi, Shohreh Jafari, Ramin Nourinia, Nastaran Mahmoudnejad, Amirhossein Nayebzadeh, Bahareh Kheiri, Mohammad Hasan Shahriari, Amir Ghaffari Jolfayi, Amirreza Veisi
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引用次数: 0

摘要

目的:探讨他达拉非对勃起功能障碍患者黄斑和视周盘脉络膜厚度、视网膜血管密度和GCC厚度的短期和长期影响。方法:纳入每隔一天服用他达拉非10mg且在过去6个月内未使用任何类型磷酸二酯酶5抑制剂(PDE5I)且视力检查正常的勃起功能障碍患者。在他达拉非治疗前(基线)、1天和3个月分别测量黄斑和视周盘脉络膜厚度、视网膜浅层和深层血管密度、黄斑神经节细胞复合体(GCC)厚度。比较治疗前后的测量结果。结果:纳入16例患者31只眼,平均年龄53.7(42 ~ 68)岁。服用他达拉非后,第1天黄斑下和视盘周围的脉络膜厚度(13.8%)和视网膜毛细血管丛浅层(9.6%)和深层(9.8%)血管密度均增加。3个月后,虽然黄斑下和乳头周围的脉络膜厚度仍比基线厚,但我们发现所有最初增加的参数都呈递减模式。视网膜神经节细胞复合体(GCC)的平均厚度在第一天和三个月后均无显著变化。结论:他达拉非可在初始用药后早期增加视网膜血管密度和脉络膜厚度,但在用药3个月后初始增量有减小的趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Tadalafil on Optical Coherence Tomography, Optical Coherence Tomography Angiography and Ganglion Cell Complex Parameters in Patients with Erectile Dysfunction.

Purpose: To investigate the short and long-term effects of Tadalafil on macular and peri-optic disc choroidal thickness, retinal vascular density, and GCC thickness in patients with erectile dysfunction.

Methods: Patients with erectile dysfunction who were candidates to treat with 10 mg of Tadalafil every other day and didn't use any type of phosphodiesterase 5 inhibitors (PDE5I) in the previous 6 months and had normal eye exams were included. Macular and peri-optic disc choroidal thickness, superficial and deep retinal vascular density, and Macular Ganglion Cell Complex (GCC) thickness were measured before (baseline), one day, and 3 months after Tadalafil treatment. The measurements before and after treatment were compared.

Results: Thirty-one eyes of 16 patients with a mean age of 53.7 (42 to 68) years were included. After Tadalafil consumption, the choroidal thickness in the sub-macular (13.8%) and peri-optic disc (14.9%) area and also the vascular density of superficial (9.6%) and deep (9.8%) retinal capillary plexus was increased on the first day. After 3 months, we found a decremental pattern in all initially increased parameters, although sub-macular and peri-papillary choroidal thickness are yet thicker than the baseline. The retinal ganglion cell complex (GCC) average thickness was not significantly changed, neither on the first day nor after three months.

Conclusions: Tadalafil can increase the retinal vascular density and choroidal thickness early after initial consumption but after 3 months the initial increment tend to decrease.

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来源期刊
Current Eye Research
Current Eye Research 医学-眼科学
CiteScore
4.60
自引率
0.00%
发文量
163
审稿时长
12 months
期刊介绍: The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.
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