癌症研究的历史：癌细胞的生长和代谢。

IF 10.1 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Cold Spring Harbor perspectives in medicine Pub Date : 2025-09-02 DOI:10.1101/cshperspect.a035782

Joseph Lipsick

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引用次数: 0

摘要

细胞生长和代谢变化的失调是肿瘤发生的一个特征。过去50年的研究已经绘制了控制细胞生长和代谢的途径，并揭示了这些途径在癌症中是如何改变的。在他即将出版的关于癌症研究历史的书的节选中，Joe Lipsick回顾了我们是如何走到这一步的——从早期对胰岛素和生长因子受体信号的研究，到发现磷脂酰肌醇3-激酶（PI 3-激酶），再到发现mTOR是雷帕霉素的靶点，以及肿瘤可以产生新的“肿瘤代谢物”的意外发现。

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A History of Cancer Research: Cancer Cell Growth and Metabolism.

Dysregulation of cell growth and metabolic changes are a feature of tumorigenesis. Studies over the past 50 years have mapped the pathways that control cell growth and metabolism and revealed how these are altered in cancer. In this excerpt from his forthcoming book on the history of cancer research, Joe Lipsick looks at how we got here-from early work on insulin and growth factor receptor signaling to the discovery of phosphatidyl inositol 3-kinase (PI 3-kinase), the identification of mTOR as the target of rapamycin, and the unexpected finding that tumors can produce novel "oncometabolites."

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来源期刊

Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

14.30

自引率

1.90%

发文量

审稿时长

4-8 weeks

期刊介绍： Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.