Bénédicte Caron, Vipul Jairath, Bruce E Sands, David T Rubin, Mariangela Allocca, Valérie Laurent, Kerri Novak, Remo Panaccione, Peter Bossuyt, David H Bruining, Axel Dignass, Iris Dotan, Joel Fletcher, Mathurin Fumery, Federica Furfaro, Jonas Halfvarson, Ailsa Hart, Taku Kobayashi, Noa Krugliak Cleveland, Torsten Kucharzik, Andrea Laghi, Peter L Lakatos, Rupert W Leong, Edward V Loftus, Edouard Louis, Fernando Magro, Pablo A Olivera, Sebastien Shaji, Britta Siegmund, Stephan R Vavricka, Silvio Danese, Jaap Stoker, Laurent Peyrin-Biroulet
{"title":"国际磁共振成像共识用于腔内克罗恩病试验和临床实践。","authors":"Bénédicte Caron, Vipul Jairath, Bruce E Sands, David T Rubin, Mariangela Allocca, Valérie Laurent, Kerri Novak, Remo Panaccione, Peter Bossuyt, David H Bruining, Axel Dignass, Iris Dotan, Joel Fletcher, Mathurin Fumery, Federica Furfaro, Jonas Halfvarson, Ailsa Hart, Taku Kobayashi, Noa Krugliak Cleveland, Torsten Kucharzik, Andrea Laghi, Peter L Lakatos, Rupert W Leong, Edward V Loftus, Edouard Louis, Fernando Magro, Pablo A Olivera, Sebastien Shaji, Britta Siegmund, Stephan R Vavricka, Silvio Danese, Jaap Stoker, Laurent Peyrin-Biroulet","doi":"10.1016/j.cgh.2025.08.019","DOIUrl":null,"url":null,"abstract":"<p><strong>Background & aims: </strong>Cross-sectional imaging is an integral part of evaluating disease activity and complications in Crohn's disease. There remains a need to develop guidance that may be for both clinical trials and clinical practice. This initiative aimed to develop consensus statements for definitions of response and remission, transmural healing, optimal timing for assessing, and evaluation of treatment efficacy in patients with Crohn's disease using magnetic resonance enterography in clinical trials and clinical practice.</p><p><strong>Methods: </strong>Thirty-three international experts (gastroenterologists [n = 29] and radiologists [n = 4] participated in a consensus process. A systematic literature review was conducted to inform initial consensus, and statements were discussed and voted on using a modified Delphi method. Consensus was defined as at least 75% agreement among voters.</p><p><strong>Results: </strong>The Magnetic Resonance Index of Activity (MaRIA) score and the simplified MaRIA score should be used to determine response and remission in moderate-to-severe Crohn's disease. Response was defined as a MaRIA score <11 or an improvement of at least 25%, and a decrease of at least 1 point in the simplified MaRIA score. Remission was defined as a MaRIA score <7 or a simplified MaRIA score <1. Five different definitions were proposed for transmural healing. For the time point of assessment, the group proposed week 24 for response; weeks 24, 52, or 54 for remission; and weeks 52 or 104 for transmural healing.</p><p><strong>Conclusions: </strong>A consensus expert panel has developed standardized definitions of magnetic resonance enterography response, remission, and the optimal timing for response assessment in patients with luminal Crohn's disease. Further research is needed to clarify the method for measuring transmural healing.</p>","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":12.0000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"International Magnetic Resonance Imaging Consensus for use in Luminal Crohn's Disease Trials and Clinical Practice.\",\"authors\":\"Bénédicte Caron, Vipul Jairath, Bruce E Sands, David T Rubin, Mariangela Allocca, Valérie Laurent, Kerri Novak, Remo Panaccione, Peter Bossuyt, David H Bruining, Axel Dignass, Iris Dotan, Joel Fletcher, Mathurin Fumery, Federica Furfaro, Jonas Halfvarson, Ailsa Hart, Taku Kobayashi, Noa Krugliak Cleveland, Torsten Kucharzik, Andrea Laghi, Peter L Lakatos, Rupert W Leong, Edward V Loftus, Edouard Louis, Fernando Magro, Pablo A Olivera, Sebastien Shaji, Britta Siegmund, Stephan R Vavricka, Silvio Danese, Jaap Stoker, Laurent Peyrin-Biroulet\",\"doi\":\"10.1016/j.cgh.2025.08.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background & aims: </strong>Cross-sectional imaging is an integral part of evaluating disease activity and complications in Crohn's disease. There remains a need to develop guidance that may be for both clinical trials and clinical practice. This initiative aimed to develop consensus statements for definitions of response and remission, transmural healing, optimal timing for assessing, and evaluation of treatment efficacy in patients with Crohn's disease using magnetic resonance enterography in clinical trials and clinical practice.</p><p><strong>Methods: </strong>Thirty-three international experts (gastroenterologists [n = 29] and radiologists [n = 4] participated in a consensus process. A systematic literature review was conducted to inform initial consensus, and statements were discussed and voted on using a modified Delphi method. Consensus was defined as at least 75% agreement among voters.</p><p><strong>Results: </strong>The Magnetic Resonance Index of Activity (MaRIA) score and the simplified MaRIA score should be used to determine response and remission in moderate-to-severe Crohn's disease. Response was defined as a MaRIA score <11 or an improvement of at least 25%, and a decrease of at least 1 point in the simplified MaRIA score. Remission was defined as a MaRIA score <7 or a simplified MaRIA score <1. Five different definitions were proposed for transmural healing. For the time point of assessment, the group proposed week 24 for response; weeks 24, 52, or 54 for remission; and weeks 52 or 104 for transmural healing.</p><p><strong>Conclusions: </strong>A consensus expert panel has developed standardized definitions of magnetic resonance enterography response, remission, and the optimal timing for response assessment in patients with luminal Crohn's disease. Further research is needed to clarify the method for measuring transmural healing.</p>\",\"PeriodicalId\":10347,\"journal\":{\"name\":\"Clinical Gastroenterology and Hepatology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":12.0000,\"publicationDate\":\"2025-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Gastroenterology and Hepatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cgh.2025.08.019\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Gastroenterology and Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.cgh.2025.08.019","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
International Magnetic Resonance Imaging Consensus for use in Luminal Crohn's Disease Trials and Clinical Practice.
Background & aims: Cross-sectional imaging is an integral part of evaluating disease activity and complications in Crohn's disease. There remains a need to develop guidance that may be for both clinical trials and clinical practice. This initiative aimed to develop consensus statements for definitions of response and remission, transmural healing, optimal timing for assessing, and evaluation of treatment efficacy in patients with Crohn's disease using magnetic resonance enterography in clinical trials and clinical practice.
Methods: Thirty-three international experts (gastroenterologists [n = 29] and radiologists [n = 4] participated in a consensus process. A systematic literature review was conducted to inform initial consensus, and statements were discussed and voted on using a modified Delphi method. Consensus was defined as at least 75% agreement among voters.
Results: The Magnetic Resonance Index of Activity (MaRIA) score and the simplified MaRIA score should be used to determine response and remission in moderate-to-severe Crohn's disease. Response was defined as a MaRIA score <11 or an improvement of at least 25%, and a decrease of at least 1 point in the simplified MaRIA score. Remission was defined as a MaRIA score <7 or a simplified MaRIA score <1. Five different definitions were proposed for transmural healing. For the time point of assessment, the group proposed week 24 for response; weeks 24, 52, or 54 for remission; and weeks 52 or 104 for transmural healing.
Conclusions: A consensus expert panel has developed standardized definitions of magnetic resonance enterography response, remission, and the optimal timing for response assessment in patients with luminal Crohn's disease. Further research is needed to clarify the method for measuring transmural healing.
期刊介绍：
Clinical Gastroenterology and Hepatology (CGH) is dedicated to offering readers a comprehensive exploration of themes in clinical gastroenterology and hepatology. Encompassing diagnostic, endoscopic, interventional, and therapeutic advances, the journal covers areas such as cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, absorption, and secretion.
As a peer-reviewed publication, CGH features original articles and scholarly reviews, ensuring immediate relevance to the practice of gastroenterology and hepatology. Beyond peer-reviewed content, the journal includes invited key reviews and articles on endoscopy/practice-based technology, health-care policy, and practice management. Multimedia elements, including images, video abstracts, and podcasts, enhance the reader's experience. CGH remains actively engaged with its audience through updates and commentary shared via platforms such as Facebook and Twitter.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
