SLFN11,远不局限于对癌症DNA损伤的反应。

IF 3.5 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Hao Xiao, Zeping Han, Yingkai Tang, Xukang Gao, Min Xu, Shuangjian Qiu, Ning Ren, Yong Yi, Chenhao Zhou
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引用次数: 0

摘要

SLFN11是进化上保守的SLFN基因家族的一员,是干扰素刺激的早期反应基因。本文将全面探讨其多方面的作用。在结构上,它的三个不同的域赋予了它不同的功能。表观遗传修饰、翻译后改变和多种信号通路复杂地调控SLFN11的表达和活性。就功能而言,它在复制应激过程中的DNA损伤反应中起着至关重要的作用,这与传统的途径不同。它还可以作为抗病毒反应的保护剂和预测dna损伤剂疗效和各种癌症患者预后的有价值的生物标志物。除此之外,SLFN11还具有非规范功能,包括免疫调节、肿瘤行为调节、参与细胞凋亡、抵抗蛋白毒性应激以及与范可尼贫血有关。展望未来,SLFN11有望成为个性化医疗的生物标志物,但开发准确的检测方法等挑战仍然存在。在免疫治疗中,了解其动态变化对优化治疗至关重要。克服slfn11低表达的策略,如表观遗传调控,也需要进一步研究,这可能为疾病治疗开辟新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

SLFN11, far from being limited to responding to cancer DNA damage.

SLFN11, far from being limited to responding to cancer DNA damage.

SLFN11, far from being limited to responding to cancer DNA damage.

SLFN11, far from being limited to responding to cancer DNA damage.

SLFN11, a member of the evolutionarily conserved SLFN gene family, is an interferon-stimulated early response gene. This review comprehensively explores its multifaceted roles. Structurally, its three distinct domains endow it with diverse functions. Epigenetic modifications, post-translational alterations, and multiple signaling pathways intricately regulate SLFN11 expression and activity. In terms of functions, it plays crucial roles in the DNA damage response during replication stress, distinct from traditional pathways. It also serves as a protector in the antiviral response and a valuable biomarker for predicting the efficacy of DNA-damaging agents and patient prognosis in various cancers. Beyond these, SLFN11 has non-canonical functions, including immune regulation, modulation of oncological behaviors, involvement in apoptosis, protection against proteotoxic stress, and association with Fanconi anemia. Looking ahead, SLFN11 holds great promise as a biomarker for personalized medicine, but challenges like developing accurate detection methods remain. In immunotherapy, understanding its dynamic changes is essential for optimizing treatment. Strategies to overcome SLFN11-low expression, such as epigenetic modulation, also need further investigation, which may open new avenues for disease treatment.

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来源期刊
Clinical and Experimental Medicine
Clinical and Experimental Medicine 医学-医学:研究与实验
CiteScore
4.80
自引率
2.20%
发文量
159
审稿时长
2.5 months
期刊介绍: Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
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