人脾细胞间室和淋巴细胞亚群的临床相关性。

IF 2.9 3区生物学 Q3 CELL BIOLOGY

Cell and Tissue Research Pub Date : 2025-10-01 Epub Date: 2025-08-29 DOI:10.1007/s00441-025-04001-0

Reinhard Pabst

{"title":"人脾细胞间室和淋巴细胞亚群的临床相关性。","authors":"Reinhard Pabst","doi":"10.1007/s00441-025-04001-0","DOIUrl":null,"url":null,"abstract":"The compartments and lymphocyte subsets of the human spleen differ from the spleen of rodents. The red pulp removes old red cells or malformed erythrocytes found in spherocytosis. The high blood flow is also necessary to filter bacteria like pneumococci from the blood. Without a spleen or after splenectomy, there is the risk of a fatal postsplenectomy sepsis. Therefore, these patients have to be vaccinated. Splenic particles can regenerate. The spleen is very important in lymphocyte recirculation and lymphocyte production. The marginal zone B lymphocytes are unique and important for B memory in man.","PeriodicalId":9712,"journal":{"name":"Cell and Tissue Research","volume":" ","pages":"109-119"},"PeriodicalIF":2.9000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484289/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical relevance of the compartments and lymphocyte subsets in the human spleen.\",\"authors\":\"Reinhard Pabst\",\"doi\":\"10.1007/s00441-025-04001-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The compartments and lymphocyte subsets of the human spleen differ from the spleen of rodents. The red pulp removes old red cells or malformed erythrocytes found in spherocytosis. The high blood flow is also necessary to filter bacteria like pneumococci from the blood. Without a spleen or after splenectomy, there is the risk of a fatal postsplenectomy sepsis. Therefore, these patients have to be vaccinated. Splenic particles can regenerate. The spleen is very important in lymphocyte recirculation and lymphocyte production. The marginal zone B lymphocytes are unique and important for B memory in man.\",\"PeriodicalId\":9712,\"journal\":{\"name\":\"Cell and Tissue Research\",\"volume\":\" \",\"pages\":\"109-119\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484289/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell and Tissue Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s00441-025-04001-0\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Tissue Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s00441-025-04001-0","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/29 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

人脾的区室和淋巴细胞亚群不同于啮齿动物的脾。红髓除去球形红细胞增多症中出现的旧红细胞或畸形红细胞。高血流量对于从血液中过滤肺炎球菌等细菌也是必要的。没有脾脏或脾切除术后，有致命的脾切除术后败血症的风险。因此，这些患者必须接种疫苗。脾颗粒可再生。脾在淋巴细胞循环和淋巴细胞生成中起着非常重要的作用。边缘区B淋巴细胞对人体B记忆是独特而重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Clinical relevance of the compartments and lymphocyte subsets in the human spleen.

The compartments and lymphocyte subsets of the human spleen differ from the spleen of rodents. The red pulp removes old red cells or malformed erythrocytes found in spherocytosis. The high blood flow is also necessary to filter bacteria like pneumococci from the blood. Without a spleen or after splenectomy, there is the risk of a fatal postsplenectomy sepsis. Therefore, these patients have to be vaccinated. Splenic particles can regenerate. The spleen is very important in lymphocyte recirculation and lymphocyte production. The marginal zone B lymphocytes are unique and important for B memory in man.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cell and Tissue Research 生物-细胞生物学

CiteScore

7.00

自引率

2.80%

发文量

142

审稿时长

1 months

期刊介绍： The journal publishes regular articles and reviews in the areas of molecular, cell, and supracellular biology. In particular, the journal intends to provide a forum for publishing data that analyze the supracellular, integrative actions of gene products and their impact on the formation of tissue structure and function. Submission of papers with an emphasis on structure-function relationships as revealed by recombinant molecular technologies is especially encouraged. Areas of research with a long-standing tradition of publishing in Cell & Tissue Research include: - neurobiology - neuroendocrinology - endocrinology - reproductive biology - skeletal and immune systems - development - stem cells - muscle biology.