啮齿动物前嗅核介导平行球间通路。

IF 4.5 1区 生物学 Q1 BIOLOGY
Li Wang, Anan Li, Sen Jin, Yue Liu, Feilong Yu, Rafi Haddad, Fan Jia, Peng Su, Jiajia Guo, Zhijian Zhang, Qing Liu, Fuqiang Xu
{"title":"啮齿动物前嗅核介导平行球间通路。","authors":"Li Wang, Anan Li, Sen Jin, Yue Liu, Feilong Yu, Rafi Haddad, Fan Jia, Peng Su, Jiajia Guo, Zhijian Zhang, Qing Liu, Fuqiang Xu","doi":"10.1186/s12915-025-02353-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Interhemispheric communication of olfactory information is crucial for accurate odor perception and odor source localization in animals. However, the underlying structural basis for this communication in mammals remains poorly understood. Using electrophysiological recordings and virus-mediated tracing, we systematically dissected the neural circuits involved in interhemispheric transmission between the bilateral olfactory bulbs (OBs).</p><p><strong>Results: </strong>We identified the anterior olfactory nucleus (AON) as a central hub that facilitates direct communication between the OBs via three distinct pathways: the excitatory inter-bulbar pathway, the inhibitory inter-bulbar pathway, and the bi-bulbar co-innervation pathway. Notably, our results highlight the differential roles of AON subregions in these pathways: the pars externa (AONpE) primarily mediates the inhibitory pathway, while the pars principalis (AONpP) participates in all three pathways. These pathways recruit CaMKIIα-positive neurons in specific AON regions, which in turn project to distinct neuronal populations within the OBs.  CONCLUSIONS: This study provides novel anatomical insights into the neural circuits underlying interhemispheric olfactory communication. The differential connectivity patterns of AON subregions contribute to a better understanding of how bilateral olfactory information is processed and transferred between the two OBs.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"271"},"PeriodicalIF":4.5000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395849/pdf/","citationCount":"0","resultStr":"{\"title\":\"Anterior olfactory nucleus mediates parallel inter-bulbar pathways in rodents.\",\"authors\":\"Li Wang, Anan Li, Sen Jin, Yue Liu, Feilong Yu, Rafi Haddad, Fan Jia, Peng Su, Jiajia Guo, Zhijian Zhang, Qing Liu, Fuqiang Xu\",\"doi\":\"10.1186/s12915-025-02353-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Interhemispheric communication of olfactory information is crucial for accurate odor perception and odor source localization in animals. However, the underlying structural basis for this communication in mammals remains poorly understood. Using electrophysiological recordings and virus-mediated tracing, we systematically dissected the neural circuits involved in interhemispheric transmission between the bilateral olfactory bulbs (OBs).</p><p><strong>Results: </strong>We identified the anterior olfactory nucleus (AON) as a central hub that facilitates direct communication between the OBs via three distinct pathways: the excitatory inter-bulbar pathway, the inhibitory inter-bulbar pathway, and the bi-bulbar co-innervation pathway. Notably, our results highlight the differential roles of AON subregions in these pathways: the pars externa (AONpE) primarily mediates the inhibitory pathway, while the pars principalis (AONpP) participates in all three pathways. These pathways recruit CaMKIIα-positive neurons in specific AON regions, which in turn project to distinct neuronal populations within the OBs.  CONCLUSIONS: This study provides novel anatomical insights into the neural circuits underlying interhemispheric olfactory communication. The differential connectivity patterns of AON subregions contribute to a better understanding of how bilateral olfactory information is processed and transferred between the two OBs.</p>\",\"PeriodicalId\":9339,\"journal\":{\"name\":\"BMC Biology\",\"volume\":\"23 1\",\"pages\":\"271\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395849/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1186/s12915-025-02353-1\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1186/s12915-025-02353-1","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:嗅觉信息的大脑间交流对于动物准确的气味感知和气味源定位至关重要。然而,哺乳动物这种交流的潜在结构基础仍然知之甚少。利用电生理记录和病毒介导的追踪,我们系统地解剖了参与双侧嗅球(OBs)之间半球间传递的神经回路。结果:我们确定了前嗅核(AON)是一个中心枢纽,通过三种不同的途径促进OBs之间的直接交流:兴奋性球间途径,抑制性球间途径和双球共神经支配途径。值得注意的是,我们的研究结果突出了AON亚区在这些通路中的不同作用:外部(AONpE)主要介导抑制通路,而主部(AONpP)参与所有三个通路。这些通路在特定的AON区域招募camkii α阳性神经元,进而投射到OBs内不同的神经元群。结论:这项研究为大脑半球间嗅觉交流的神经回路提供了新的解剖学见解。AON子区域的不同连接模式有助于更好地理解双侧嗅觉信息是如何在两个ob之间处理和传递的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anterior olfactory nucleus mediates parallel inter-bulbar pathways in rodents.

Background: Interhemispheric communication of olfactory information is crucial for accurate odor perception and odor source localization in animals. However, the underlying structural basis for this communication in mammals remains poorly understood. Using electrophysiological recordings and virus-mediated tracing, we systematically dissected the neural circuits involved in interhemispheric transmission between the bilateral olfactory bulbs (OBs).

Results: We identified the anterior olfactory nucleus (AON) as a central hub that facilitates direct communication between the OBs via three distinct pathways: the excitatory inter-bulbar pathway, the inhibitory inter-bulbar pathway, and the bi-bulbar co-innervation pathway. Notably, our results highlight the differential roles of AON subregions in these pathways: the pars externa (AONpE) primarily mediates the inhibitory pathway, while the pars principalis (AONpP) participates in all three pathways. These pathways recruit CaMKIIα-positive neurons in specific AON regions, which in turn project to distinct neuronal populations within the OBs.  CONCLUSIONS: This study provides novel anatomical insights into the neural circuits underlying interhemispheric olfactory communication. The differential connectivity patterns of AON subregions contribute to a better understanding of how bilateral olfactory information is processed and transferred between the two OBs.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
BMC Biology
BMC Biology 生物-生物学
CiteScore
7.80
自引率
1.90%
发文量
260
审稿时长
3 months
期刊介绍: BMC Biology is a broad scope journal covering all areas of biology. Our content includes research articles, new methods and tools. BMC Biology also publishes reviews, Q&A, and commentaries.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信