多发性骨髓瘤患者深静脉血栓形成的危险因素及治疗策略研究

IF 2.6 4区 医学 Q3 ONCOLOGY
Cancer Management and Research Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI:10.2147/CMAR.S533589
Yifei Guo, Lixiang Yan, Xi Yang, Chenyang Fan, Jianati Reaila, Yanan Jia, Xiaogang Hao, Feng Ju, Zhexin Shi
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引用次数: 0

摘要

多发性骨髓瘤(Multiple myeloma, MM)是一种起源于浆细胞的恶性肿瘤,近年来其发病率在我国呈明显上升趋势。静脉血栓栓塞(VTE)是多发性骨髓瘤(MM)患者相对常见的并发症。静脉血栓栓塞包括深静脉血栓形成(DVT)和肺栓塞(PE),患者在治疗过程中面临DVT的高风险。研究表明MM的促凝状态、炎症反应以及所使用的治疗药物显著增加了DVT的发生率。然而,静脉血栓形成风险增加背后的确切机制尚不完全清楚。深静脉血栓的发生不仅会严重影响患者的生存率,还会导致治疗方案的调整和患者生活质量的下降。本文分析了DVT与MM危险因素之间的关系,探讨了目前DVT的诊断方法、风险评估工具以及个性化的预防治疗策略,并提出了未来的研究方向。通过对相关文献的回顾和分析,旨在提高对多发性骨髓瘤和深静脉血栓形成的认识,为临床诊断和治疗提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study on Risk Factors and Treatment Strategies for Deep Vein Thrombosis in Patients with Multiple Myeloma.

Multiple myeloma (MM) is a malignant tumor originating from plasma cells, and in recent years, its incidence has shown a significant upward trend in our country. Venous thromboembolism (VTE) is a relatively common complication in multiple myeloma (MM) patients. Venous thromboembolism includes deep vein thrombosis (DVT) and pulmonary embolism (PE), with patients facing a high risk of DVT during treatment. Studies have shown that the procoagulant state of MM, inflammatory response, and the therapeutic drugs used significantly increase the incidence of DVT. However, the exact mechanisms behind the increased risk of venous thrombosis are not yet fully understood. The occurrence of DVT not only has a severely negative impact on patient survival rates but also leads to adjustments in treatment plans and a reduction in patients' quality of life. This article analyzes the relationship between risk factors for DVT and MM, exploring current diagnostic methods, risk assessment tools, and personalized preventive treatment strategies, ultimately proposing future research directions. Through a review and analysis of relevant literature, it aims to enhance the understanding of multiple myeloma and deep vein thrombosis, providing references for clinical diagnosis and treatment.

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来源期刊
Cancer Management and Research
Cancer Management and Research Medicine-Oncology
CiteScore
7.40
自引率
0.00%
发文量
448
审稿时长
16 weeks
期刊介绍: Cancer Management and Research is an international, peer reviewed, open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for cancer patients. Specific topics covered in the journal include: ◦Epidemiology, detection and screening ◦Cellular research and biomarkers ◦Identification of biotargets and agents with novel mechanisms of action ◦Optimal clinical use of existing anticancer agents, including combination therapies ◦Radiation and surgery ◦Palliative care ◦Patient adherence, quality of life, satisfaction The journal welcomes submitted papers covering original research, basic science, clinical & epidemiological studies, reviews & evaluations, guidelines, expert opinion and commentary, and case series that shed novel insights on a disease or disease subtype.
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