糠麦芽素的合成及其抗菌活性研究。

IF 1.3 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-08-20 DOI:10.1093/bbb/zbaf125

Md Masud Rana, Taku Oshima, Ei Horiuchi, Issay Osaka, Yasuhiro Igarashi, Daisuke Urabe

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引用次数: 0

摘要

本文报道了一种天然存在的马来酰亚胺，通过自由基介导的异丙基引入到溴马来酸酐上，并与β-丙氨酸一锅生成马来酰亚胺，一步合成了farinomalein A。用该方法合成的天然和非天然的粉马莱素的抗菌测试表明，粉马莱素A和一些非天然类似物对枯草芽孢杆菌有活性，一种非天然类似物对大肠杆菌有活性。细胞形态学研究表明，粉蛋白A可能对细菌膜和/或细胞壁功能有抑制作用。

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Synthesis of Farinomaleins and their Antimicrobial Activities.

A single-step synthesis of farinomalein A, a naturally occurring maleimide, by the radical-mediated introduction of an isopropyl group to bromomaleic anhydride and one-pot maleimide formation with β-alanine is reported. Antimicrobial testing of natural and unnatural farinomaleins synthesized using this protocol demonstrates that farinomalein A and some unnatural analogs are active against Bacillus subtilis, and one unnatural analog is active against Escherichia coli. The possible inhibitory activity of bacterial membrane and/or cell wall functions of farinomalein A was indicated by cell morphological studies.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).