2型糖尿病低度炎症与远端感觉运动多神经病变的相关性:一项横断面研究。

IF 2.2 3区 医学 Q3 CLINICAL NEUROLOGY
Sihua Huang, Yan Lan, Cheng Zheng, Hongyun Liang, Yanhong Wei, Bing Chen
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引用次数: 0

摘要

背景:由于炎症过程可能参与糖尿病远端感觉运动多神经病变(DSPN)的发病机制,本研究的第一个目的是确定2型糖尿病(T2DM)伴远端感觉运动多神经病变(DSPN)的临床特征。下一个目标是研究这些患者的炎症生物标志物、胰岛素样生长因子- 1和脂质谱。最后,我们的目的是比较这些患者的肾功能。方法:在一项横断面研究中,我们纳入了160例诊断为T2DM的患者。对照组为22例非糖尿病健康人(HC)。将糖尿病患者分为四组,无(n = 74)、轻度(n = 38)、中度(n = 24)和重度(n = 24),采用基于MNSI特征的nomogram DSPN严重程度分级概率。结果:与无DSPNS和轻度DSPNS患者相比,中度和重度DSPN患者年龄稍大,糖尿病持续时间更长(p)。结论:T2DM合并重度DSPN患者炎症生物标志物如INF-γ、IL-1β、IL-4、IL- 6水平升高。年龄、糖尿病病程以及高循环水平的IL-6、IL-1β、TC、LDL-C和胱抑素C与T2DM患者的DSPN呈正相关。相反,IGF-1水平和APOA1/APOB比值是T2DM患者DSPN的独立保护因素。我们的研究结果强调了在T2DM合并DSPN患者中解决炎症生物标志物、脂质和早期肾功能受损相关问题的重要性,因为这些问题可能与DSPN恶化有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between low-grade inflammation and distal sensorimotor polyneuropathy in type 2 diabetes: a cross-sectional study.

Association between low-grade inflammation and distal sensorimotor polyneuropathy in type 2 diabetes: a cross-sectional study.

Association between low-grade inflammation and distal sensorimotor polyneuropathy in type 2 diabetes: a cross-sectional study.

Background: As inflammatory processes may be involved in the pathogenesis of diabetic distal sensorimotor polyneuropathy (DSPN), the first aim of the present study was to determine the clinical characteristics of type 2 diabetes mellitus (T2DM) with distal sensorimotor polyneuorpathy (DSPN). Next goal was to investigate inflammatory biomarkers, insulin-like growth factor- 1 and lipid profile in these patients. Finally, we aimed to compare the renal function in these patients.

Methods: In a cross-sectional study, we included 160 patients diagnosed with T2DM. The control group was included 22 non-diabetic healthy subjects (HC). The patients with diabetes were divided into four groups, absent (n = 74), mild (n = 38), moderate (n = 24), and severe (n = 24) using a nomogram based on the MNSI features for a DSPN severity grading probability.

Results: Patients with moderate and severe DSPN were a little older and had longer duration of diabetes compared to patients with absent and mild DSPNS (p < 0.05). Serum levels of interferon-gamma (INF-γ), interleukin (IL)-1β, IL-4, IL- 6 levels in patients with severe DSPN were significantly higher than HC, absent, mild and moderate of DSPN (p < 0.05). The circulating levels of insulin-like growth factor-1 (IGF-1) were significantly lower in patients with severe DSPN (p < 0.05) compared to absent, mild and moderate of DSPN and HC. Diabetic patients with moderate DSPN showed increased circulating levels of TC, LDL-C, APOB (p < 0.05) compared to HC and patients with absent, mild and severe DSPN. Moreover, APO-A1/APOB was significantly lower in patients with diabetes compared to HC. In addition, patients with severe DSPN showed increased Cystatin C (p < 0.05) compared to HC and absent, mild, and moderate DSPN. Multivariate ordered logistic regression analysis showed that the levels of IL-6 (OR = 3.166, 95%CI 1.461-6.860, p = 0.003, IL-1β(OR = 1.148, 95%CI 1.070-2.232; p = 0.000), TC (OR = 1.174, 95%CI 1.011-1.364; p = 0.035), LDL-C (OR = 1.246, 95%CI 1.098-3.618; p = 0.003), Cystatin C (OR = 1.867, 95%CI 1.245-3.434; p = 0.004), ages (OR = 1.043, 95%CI 1.009-1.078; p = 0.012), and duration of diabetes (OR = 1.157, 95%CI 1.049-1.277; p = 0.004) were positively associated with increasing the odds ration of DSPN in T2DM. Conversely, the level of IGF-1 (OR = 0.922, 95%CI 0.961-0.982; p = 0.000) and ratio of APO-A1/APOB (OR = 0.212, 95%CI 0.078-0.567; p = 0.002) were significantly associated with decreasing the odds ratio of DSPN in T2DM.

Conclusions: The levels of inflammatory biomarkers such as INF-γ, IL-1β, IL-4, IL- 6 were increased in patients with severe DSPN in T2DM. Ages, duration of diabetes as well as high circulating levels of IL-6, IL-1β, TC, LDL-C and Cystatin C were positively associated with DSPN in T2DM. Conversely, the level of IGF-1 and the ratio of APOA1/APOB were independent protective factors for DSPN in T2DM. Our results emphasize the importance of addressing issues related to inflammatory biomarkers, lipids and early impaired renal function in T2DM with DSPN, as these may be of potential relevance for deteriorating DSPN.

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来源期刊
BMC Neurology
BMC Neurology 医学-临床神经学
CiteScore
4.20
自引率
0.00%
发文量
428
审稿时长
3-8 weeks
期刊介绍: BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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