抗酸药的使用与自我报告的中风之间的关系。

IF 2.2 3区 医学 Q3 CLINICAL NEUROLOGY
Xiaoqu Zuo, Xinghai Yue, Hongwu Tao
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引用次数: 0

摘要

背景:质子泵抑制剂(PPIs)与脑卒中之间的关系仍然存在争议,而H2受体拮抗剂(H2RAs)与脑卒中的关系研究较少。本研究旨在利用1999-2018年美国国家健康与营养调查(NHANES)的数据,探讨ppi、H2RAs和总体抑酸药物与卒中之间的关系。方法:从NHANES处方药调查中获得过去一个月的抑酸药使用数据,将使用PPIs或H2RAs的个体归类为抑酸药使用者。卒中数据来源于疾病问卷。采用倾向评分匹配(PSM)来减少组间差异,然后采用加权多变量逻辑回归和亚组分析来检查抑酸药使用(包括PPIs和H2RAs的使用)与卒中之间的关系。结果:匹配前共纳入受试者54918人,其中抑酸药使用者5776人(10.5%)。551例(9.5%)盐酸抑制剂使用者发生中风,49142例非使用者中有1643例(3.3%)发生中风。在1:3倾向评分匹配后,保留了14,390名参与者,其中包括3,740名抑酸使用者和10,650名非使用者。其中,316名使用者(8.4%)和614名非使用者(5.8%)报告曾中风。加权logistic回归分析显示抑酸药的使用与脑卒中有显著相关性。匹配前的相关性仍具有统计学意义(OR: 1.37, 95% CI: 1.15-1.63, P)。结论:我们的研究结果提示,使用抑酸药物与脑卒中之间存在显著关联,但由于横断面研究设计和自我报告数据的局限性,这一结果需要在未来的研究中进一步验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between acid-suppressant use and self-reported stroke.

Association between acid-suppressant use and self-reported stroke.

Association between acid-suppressant use and self-reported stroke.

Association between acid-suppressant use and self-reported stroke.

Background: The association between proton pump inhibitors (PPIs) and stroke remains controversial, while H2 receptor antagonists (H2RAs) have been less studied in relation to stroke. This study aimed to explore the relationship between PPIs, H2RAs, and overall acid-suppressant medications with stroke using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018.

Methods: Data on acid-suppressant use were obtained from the NHANES prescription medication survey for the past month, classifying individuals using PPIs or H2RAs as acid-suppressant users. Stroke data were derived from the disease questionnaire. Propensity score matching (PSM) was applied to reduce intergroup differences, followed by weighted multivariable logistic regression and subgroup analyses to examine the association between acid-suppressant use (including the use of PPIs and H2RAs) and stroke.

Results: A total of 54,918 participants were included before matching, among whom 5,776 (10.5%) were acid-suppressant users. Stroke was reported in 551 (9.5%) acid-suppressant users and in 1,643 (3.3%) of the 49,142 non-users. After 1:3 propensity score matching, 14,390 participants were retained, including 3,740 acid-suppressant users and 10,650 non-users. Among them, 316 users (8.4%) and 614 non-users (5.8%) reported having had a stroke. Weighted logistic regression analysis indicated a significant association between acid-suppressant use and stroke. The association remained statistically significant both before matching (OR: 1.37, 95% CI: 1.15-1.63, P < 0.001) and after matching (OR: 1.33, 95% CI: 1.10-1.60, P = 0.003). In addition, the association between H2RA use and stroke remained significant before and after matching, whereas the association between PPI use and stroke appeared less stable, showing borderline significance.

Conclusion: Our findings suggest a significant association between the use of acid-suppressive medications and stroke; however, due to the limitations of cross-sectional study design and self-reported data, this result requires further verification in future research.

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来源期刊
BMC Neurology
BMC Neurology 医学-临床神经学
CiteScore
4.20
自引率
0.00%
发文量
428
审稿时长
3-8 weeks
期刊介绍: BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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