ETRAISI注册报告:符合再灌注条件的AIS患者的临床特征和相关因素。

IF 2.2 3区 医学 Q3 CLINICAL NEUROLOGY
Mojdeh Ghabaee, Sharareh Eskandarieh, Neda Izadi, Siavash Hosseini, Iman Kiani, Melika Jameie, Zahra Azizan, Nahid Mojahed
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引用次数: 0

摘要

背景:中风仍然是世界范围内致残和死亡的主要原因,需要全面的数据收集来制定更好的管理策略。伊朗急性缺血性卒中血管内溶栓登记(ETRAISI)成立于2023年3月21日,旨在系统地记录伊朗的卒中流行病学、治疗方法和结果。本研究对注册数据进行分析,重点关注患者特征、治疗时间尺度和功能结果。方法:在2023年3月21日至2024年3月19日期间,共有115例诊断为急性脑卒中的患者入组ETRAISI。收集临床和人口统计数据,包括脑卒中亚型、危险因素、治疗方式和结果测量。分析溶栓的门到针时间(DTN)和取栓的门到腹股沟穿刺时间(DTP)等治疗时间尺度。出院时与美国国立卫生研究院卒中量表(NIHSS)相关的因素采用多元线性回归进行评估。结果:在313例可能为急性缺血性卒中(AIS)住院的患者中,共有158例患者在发病6小时内候选静脉溶栓(IVT)或机械取栓(MT), 115例入组,81例(70.4%)患者接受IVT, 8例(7.0%)患者接受MT, 26例(22.6%)患者接受桥接治疗。最常见的卒中危险因素是高血压(77例,占67.0%),其次是糖尿病(39例,占33.9%)和缺血性心脏病(33例,占28.7%)。DTN的中位(IQR)为65 (48 ~ 84.5)min, DTP的中位(IQR)为109 (75 ~ 158)min。在33%的患者中观察到最常见的卒中病因不明。多元线性回归确定了入院时国立卫生研究院卒中量表(NIHSS)、年龄、舒张压和治疗相关并发症与功能结局显著相关(p结论:本研究报告了伊朗的卒中管理和结局。确定治疗时间跟踪器和结果相关因素可能为伊朗和其他发展中国家的政策变化提供信息,并改善急性卒中护理。将这些发现与国际注册对照,可以指导有针对性的干预措施,以优化卒中治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

ETRAISI registry report: clinical characteristics and related factors of outcome in reperfusion-eligible AIS patients.

ETRAISI registry report: clinical characteristics and related factors of outcome in reperfusion-eligible AIS patients.

Background: Stroke remains a major cause of disability and mortality worldwide, requiring comprehensive data collection for better management strategies. The Endovascular Thrombolysis Registry in Acute Ischemic Stroke of Iran (ETRAISI) was established March 21, 2023, to systematically document stroke epidemiology, treatment approaches, and outcomes in Iran. This study presents an analysis of registry data, focusing on patient characteristics, treatment time scales, and functional outcomes.

Methods: A total of 115 patients diagnosed with acute stroke were enrolled at ETRAISI between March 21, 2023, and March 19, 2024. Clinical and demographic data, including stroke subtype, risk factors, treatment modalities, and outcome measures, were collected. Treatment time scales, such as door-to-needle time (DTN) for thrombolysis and door-to-groin puncture time (DTP) for thrombectomy, were analyzed. Factors associated with National Institutes of Health Stroke Scale (NIHSS) at discharge were assessed using multiple linear regression.

Results: Among 313 patients admitted at hospital as possible acute ischemic stroke (AIS), a total of 158 patients' candidate for intra-venous thrombolysis (IVT) or mechanical thrombectomy (MT) within 6-hours of onset, 115 enrolled, 81 patients (70.4%) underwent IVT, 8 (7.0%) patients received MT, and 26 patients (22.6%) underwent bridging therapy. The most common stroke risk factors were hypertension in 77 patients (67.0%), followed by diabetes in 39 (33.9%), and ischemic heart disease in 33 patients (28.7%). The median (IQR) of DTN was 65 (48-84.5) minutes, while the median (IQR) of DTP was 109 (75-158) minutes. The most frequent stroke etiology was undetermined observed in 33% patients. Multiple linear regression identified National Institutes of Health Stroke Scale (NIHSS) at admission, age, diastolic blood pressure, and treatment related complication were significantly associated with functional outcomes (p < 0.05).

Conclusion: This study reported stroke management and outcomes in Iran. Identifying treatment time tracker and outcome related factors may inform policy changes and improve acute stroke care in Iran and Other developing countries. Benchmarking these findings against international registries can guide targeted interventions for optimizing stroke treatment.

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来源期刊
BMC Neurology
BMC Neurology 医学-临床神经学
CiteScore
4.20
自引率
0.00%
发文量
428
审稿时长
3-8 weeks
期刊介绍: BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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