The complex inflammatory indexes predict the prognostic risk for patients with acute coronary syndrome undergoing percutaneous coronary intervention.

Introduction: An accurate assessment of prognostic risk is widely recognized to be important in improving the survival of patients with acute coronary syndrome (ACS). This study aimed to investigate the roles of neutrophil-to-lymphocyte * platelet (NLPR) and neutrophil-lymphocyte (NLR) ratios with high- and (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels in predicting the risk of major adverse cardiovascular events (MACEs) in patients with ACS undergoing percutaneous coronary intervention (PCI).

Results: Overall, 1,263 patients with ACS undergoing PCI between January 2016 and December 2018 were consecutively enrolled. The patients were divided into MACEs (n = 54) and non-MACEs (n = 1,209) groups. The study endpoints were MACEs, including cardiac-related mortality and re-hospitalization for severe heart failure (HF), myocardial infarction (MI), and in-stent restenosis (ISR). The Kaplan-Meier curve showed the low NLPR and NLR groups had higher cumulative survival than the high NLPR and NLR group. Patients with high NLPR/HDL-C, NLPR×LDL-C, NLR/HDL-C, and NLR×LDL-C also had significantly lower cumulative survival.

Conclusion: NLPR ≥ 2.843, NLPR/HDL-C ≥ 1.977, NLPR*LDL-C ≥ 4.608, NLR ≥ 0.025, NLR/HDL-C ≥ 0.030, and NLR*LDL-C ≥ 0.038 were all independent prognostic risk factors in patients with ACS undergoing PCI, which may be useful markers for long prognosis.