果糖增强固体和软饮料饮食对妊娠大鼠代谢、生理和肠道微生物组的影响。

IF 2.3 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BioMed Research International Pub Date : 2025-08-13 eCollection Date: 2025-01-01 DOI:10.1155/bmri/6902453
Xiaoyuan Han, Linda D Shortliffe, Neeraja Kambham
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引用次数: 0

摘要

导读:高果糖摄入与高血压和代谢紊乱有关。我们假设果糖(固体和/或液体)可能进一步影响饮食模式。为了研究潜在的影响,我们比较了喂食固体或液体果糖增强饮食(软饮料)和喂食标准食物的怀孕大鼠的饮食行为、生理和代谢指标以及肠道微生物群。方法:将怀孕大鼠分为3个饮食组:(1)标准食物加水(CW),(2)标准食物加脱碳软饮料(CS,含5.89%果糖w/v的脱碳雪碧),(3)60%果糖的食物加水(FW)。每周测量体重、血压、食物和液体摄入量、空腹血糖、血浆胰岛素和血脂。在怀孕前和怀孕期间收集粪便样本。在安乐死时,分析肝脏和肾脏的病理变化。结果:每组5只大鼠进行数据分析。CS组在妊娠中期的液体摄入量和尿量增加了近两倍。固体和液体果糖组每公斤体重的碳水化合物卡路里摄入量都有所增加,而蛋白质和脂肪摄入量则有所减少。虽然所有的大鼠都表现出与妊娠相关的血脂异常,但FW组的升高更为明显。怀孕和FW饮食也会导致粪便肠道微生物群的明显变化。结论:该怀孕大鼠模型强调了生理应激期间不同果糖饮食的影响。与常规饮食的怀孕大鼠相比,高果糖饮食的怀孕大鼠(CS, FW)增加了碳水化合物的摄入量,以牺牲蛋白质和脂肪的摄入量为代价。CS大鼠的软饮料摄入量和尿量明显增加。这些发现对怀孕和长期健康具有潜在的营养和健康影响,值得进一步调查和证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Impact of Fructose-Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats.

Impact of Fructose-Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats.

Impact of Fructose-Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats.

Impact of Fructose-Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats.

Introduction: High fructose consumption is linked to hypertension and metabolic disorders. We hypothesize fructose (solid and/or liquid) may further influence dietary patterns. To investigate potential effects, we compared eating behaviors, physiological and metabolic measures, and gut microbiome in pregnant rats fed solid or liquid fructose-enhanced (soft drink) diets to those fed standard chow. Methods: Pregnant rats were assigned to three dietary groups: (1) standard chow and water (CW), (2) standard chow and decarbonated soft drink (CS, decarbonated Sprite with 5.89% fructose w/v), and (3) 60% fructose chow and water (FW). Body weight, blood pressure, food and liquid intake, fasting blood glucose, plasma insulin, and lipid profiles were measured weekly. Fecal samples were collected before and during pregnancy. At euthanasia, livers and kidneys were analyzed for pathological changes. Results: Data from five rats per group were analyzed. The CS group showed nearly a twofold increase in fluid intake and urinary output at midpregnancy. Both solid and liquid fructose groups had increased carbohydrate calorie intake per kilogram of body weight, while protein and fat intake decreased. Although all rats showed pregnancy-related dyslipidemia, the FW group experienced a more pronounced increase. Pregnancy and the FW diet also led to distinct shifts in the fecal gut microbiome. Conclusions: This pregnant rat model highlights the impact of varying fructose diets during physiological stress. Pregnant rats on high-fructose diets (CS, FW) increased their carbohydrate intake at the expense of protein and fat intake when compared with pregnant rats on a routine diet. CS rats showed a marked increase in soft drink intake and urine. These findings have potential nutritional and health implications for pregnancy and long-term health and warrant further investigation and confirmation.

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来源期刊
BioMed Research International
BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.70
自引率
0.00%
发文量
1942
审稿时长
19 weeks
期刊介绍: BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
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