M A Kudimova, L M Mikhaleva, I A Krasnova, V G Breusenko, I A Esipova, S A Mikhalev, N A Gracheva
{"title":"子宫动脉栓塞前后子宫平滑肌瘤子宫内膜的形态功能特征。","authors":"M A Kudimova, L M Mikhaleva, I A Krasnova, V G Breusenko, I A Esipova, S A Mikhalev, N A Gracheva","doi":"10.17116/patol20258704113","DOIUrl":null,"url":null,"abstract":"<p><p>The question of the degree of influence of uterine artery embolization (UAE) on fertility is open. It is important to evaluate the pathomorphological structure and functional activity of the endometrium, the disruption of which can lead to infertility.</p><p><strong>Objective: </strong>To study morpho-functional changes in the endometrium of patients with uterine fibroids before and after UAE.</p><p><strong>Material and methods: </strong></p><p><p>116 patients were divided into 2 groups depending on the type of the leading fibroid node: 1<sup>st</sup> - 54 patients examined with uterine fibroid (UF) types 2, 2-5, 3, 2<sup>nd</sup> - 62 patients observed with UM types 4, 5, 6.</p><p><p>The comparison group - 30 healthy women. Aspiration biopsy of the endometrium was performed in the middle stage of the secretory phase before and 6-12 months after UAE. The percentage and maturity of pinopodes, the expression level of estrogen (ER), progesterone (PR) receptors in the glands, endometrial stroma, inflammatory markers (CD56+, CD138+) were determined.</p><p><strong>Results: </strong>The negative impact of UF on the morpho-functional state of the endometrium was determined. Changes were more pronounced in patients of 1<sup>st</sup> group. Stroma indices before and after UAE corresponded to comparison group in most patients. After UAE, the number of mature pinopodes decreased in 1<sup>st</sup> group, but not in 2<sup>nd</sup> group. ER and PR expression levels in the glandular component decreased in all patients, being consistently higher in 1<sup>st</sup> group. An increase in proinflammatory markers was observed only in 1<sup>st</sup> group.</p><p><strong>Conclusion: </strong>UF and UAE can disturb morpho-functional state of the endometrium. The impact assessment should be made taking into account the topographic and anatomical location of the myomatous node.</p>","PeriodicalId":8548,"journal":{"name":"Arkhiv patologii","volume":"87 4","pages":"13-23"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Morpho-functional features of the endometrium in uterine leiomyoma before and after embolization of the uterine arteries].\",\"authors\":\"M A Kudimova, L M Mikhaleva, I A Krasnova, V G Breusenko, I A Esipova, S A Mikhalev, N A Gracheva\",\"doi\":\"10.17116/patol20258704113\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The question of the degree of influence of uterine artery embolization (UAE) on fertility is open. It is important to evaluate the pathomorphological structure and functional activity of the endometrium, the disruption of which can lead to infertility.</p><p><strong>Objective: </strong>To study morpho-functional changes in the endometrium of patients with uterine fibroids before and after UAE.</p><p><strong>Material and methods: </strong></p><p><p>116 patients were divided into 2 groups depending on the type of the leading fibroid node: 1<sup>st</sup> - 54 patients examined with uterine fibroid (UF) types 2, 2-5, 3, 2<sup>nd</sup> - 62 patients observed with UM types 4, 5, 6.</p><p><p>The comparison group - 30 healthy women. Aspiration biopsy of the endometrium was performed in the middle stage of the secretory phase before and 6-12 months after UAE. The percentage and maturity of pinopodes, the expression level of estrogen (ER), progesterone (PR) receptors in the glands, endometrial stroma, inflammatory markers (CD56+, CD138+) were determined.</p><p><strong>Results: </strong>The negative impact of UF on the morpho-functional state of the endometrium was determined. Changes were more pronounced in patients of 1<sup>st</sup> group. Stroma indices before and after UAE corresponded to comparison group in most patients. After UAE, the number of mature pinopodes decreased in 1<sup>st</sup> group, but not in 2<sup>nd</sup> group. ER and PR expression levels in the glandular component decreased in all patients, being consistently higher in 1<sup>st</sup> group. An increase in proinflammatory markers was observed only in 1<sup>st</sup> group.</p><p><strong>Conclusion: </strong>UF and UAE can disturb morpho-functional state of the endometrium. The impact assessment should be made taking into account the topographic and anatomical location of the myomatous node.</p>\",\"PeriodicalId\":8548,\"journal\":{\"name\":\"Arkhiv patologii\",\"volume\":\"87 4\",\"pages\":\"13-23\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arkhiv patologii\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17116/patol20258704113\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arkhiv patologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/patol20258704113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
[Morpho-functional features of the endometrium in uterine leiomyoma before and after embolization of the uterine arteries].
The question of the degree of influence of uterine artery embolization (UAE) on fertility is open. It is important to evaluate the pathomorphological structure and functional activity of the endometrium, the disruption of which can lead to infertility.
Objective: To study morpho-functional changes in the endometrium of patients with uterine fibroids before and after UAE.
Material and methods:
116 patients were divided into 2 groups depending on the type of the leading fibroid node: 1st - 54 patients examined with uterine fibroid (UF) types 2, 2-5, 3, 2nd - 62 patients observed with UM types 4, 5, 6.
The comparison group - 30 healthy women. Aspiration biopsy of the endometrium was performed in the middle stage of the secretory phase before and 6-12 months after UAE. The percentage and maturity of pinopodes, the expression level of estrogen (ER), progesterone (PR) receptors in the glands, endometrial stroma, inflammatory markers (CD56+, CD138+) were determined.
Results: The negative impact of UF on the morpho-functional state of the endometrium was determined. Changes were more pronounced in patients of 1st group. Stroma indices before and after UAE corresponded to comparison group in most patients. After UAE, the number of mature pinopodes decreased in 1st group, but not in 2nd group. ER and PR expression levels in the glandular component decreased in all patients, being consistently higher in 1st group. An increase in proinflammatory markers was observed only in 1st group.
Conclusion: UF and UAE can disturb morpho-functional state of the endometrium. The impact assessment should be made taking into account the topographic and anatomical location of the myomatous node.
期刊介绍：
The journal deals with original investigations on pressing problems of general pathology and pathologic anatomy, newest research methods, major issues of the theory and practice as well as problems of experimental, comparative and geographic pathology. To inform readers latest achievements of Russian and foreign medicine the journal regularly publishes editorial and survey articles, reviews of the most interesting Russian and foreign books on pathologic anatomy, new data on modern methods of investigation (histochemistry, electron microscopy, autoradiography, etc.), about problems of teaching, articles on the history of pathological anatomy development both in Russia and abroad.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
