[结节样反应伴局灶性间质纤维化，结节样肉芽肿和肺组织中持续存在Sars-Cov-2病毒核衣壳和粘附蛋白]。

Q4 Medicine

Arkhiv patologii Pub Date : 2025-01-01 DOI:10.17116/patol20258704154

E A Kogan, S A Demura, M A Afonina

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引用次数: 0

摘要

报告1例新型冠状病毒感染后肺结节病合并纤维化。对肺活检进行Sars-Cov2核衣壳和粘附蛋白的形态学和免疫组织化学分析。在肺泡巨噬细胞、二级肺细胞和细支气管上皮以及肉芽肿相关巨噬细胞、多核Pirogov-Langhans细胞中检测到病毒蛋白，表明Sars-Cov2持续存在。同时，肉芽肿细胞和间质巨噬细胞释放促炎细胞因子导致组织损伤和肺纤维化。

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[Sarcoid reaction with focal interstitial fibrosis in a COVID-19 patient with persistence of Sars-Cov-2 virus nucleocapsid and adhesion proteins in sarcoid granulomas and lung tissue].

A case report of pulmonary sarcoidosis with fibrosis after COVID-19 is presented. Morphologic and immunohistochemical analysis of lung biopsies for Sars-Cov2 nucleocapsid and adhesion proteins was performed. Virus proteins were detected in alveolar macrophages, second-order pneumocytes and bronchiolar epithelium, also in granuloma-associated macrophages, multinucleated Pirogov-Langhans cells, indicating Sars-Cov2 persistence. Meanwhile, release of pro-inflammatory cytokines by granuloma cells and interstitial macrophages resulted in tissue damage and pulmonary fibrosis.

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来源期刊

Arkhiv patologii Medicine-Pathology and Forensic Medicine

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The journal deals with original investigations on pressing problems of general pathology and pathologic anatomy, newest research methods, major issues of the theory and practice as well as problems of experimental, comparative and geographic pathology. To inform readers latest achievements of Russian and foreign medicine the journal regularly publishes editorial and survey articles, reviews of the most interesting Russian and foreign books on pathologic anatomy, new data on modern methods of investigation (histochemistry, electron microscopy, autoradiography, etc.), about problems of teaching, articles on the history of pathological anatomy development both in Russia and abroad.