盐生植物煎提物减轻类人啮齿类动物模型大鼠的代谢和组织病理学紊乱。

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-08-20 DOI:10.1080/13813455.2025.2541695

Yosr Z Haffani, Souhaieb Chrigui, Ramla Khiari, Mohamed Bessem Hammami, Sameh Hadj Taieb, Moncef Feki, Rafika Ben Chaouacha-Chekir, Nourhène Boudhrioua

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引用次数: 0

摘要

背景：研究了盐生植物“阿拉伯海角”煎提物（HDE）对高热量饮食（HCD）诱导的肥胖沙门（Psammomys obesus）组织损伤和代谢紊乱的影响。方法：将40只肥胖胖鼠分为两组，分别饲喂天然低热量饮食（LCD）和高热量饮食（HCD）。在第90天，每组进一步细分为两组，每天口服HDE 300 mg/kg体重，持续1个月。评估体重、血糖和血脂。第120天对视网膜、胰腺、肾脏和脂肪组织进行组织病理学分析。结果：与未给药的HCD组相比，HDE给药明显减轻了HCD诱导的代谢紊乱和组织病理学改变，恢复了组织完整性。ATR-FTIR和微量营养素分析显示，HDE含有抗氧化矿物质、可溶性膳食纤维和酚类化合物，可能是其作用的原因。结论：HDE对肥胖大鼠hcd诱导的代谢紊乱和组织改变具有保护作用。

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Halophyte decocted extract alleviates metabolic and histopathological disturbances induced in human-like rodent model, Psammomys obesus.

Background: The effect of halophyte plant "Salicornia arabica" decocted extract (HDE) on histological damage and metabolic disorders induced by a High-Caloric Diet (HCD) in Psammomys obesus (P. obesus) was investigated.

Methods: Forty P. obesus were divided into two groups: receiving a natural Low-Caloric Diet (LCD) or a high-caloric diet (HCD). On day 90, each group was further subdivided into two groups, with or without a daily oral administration of HDE at 300 mg/kg body weight for one month. Body weight, glycaemia, and serum lipid profile were assessed. Histopathological analyses on retinal, pancreatic, renal, and adipose tissues were conducted on day 120.

Results: HDE administration markedly alleviates the HCD-induced metabolic disorder and histopathological alterations, restoring tissue integrity compared to the untreated HCD group. ATR-FTIR and micronutrient analyses showed HDE contains antioxidant minerals, soluble dietary fibers, and phenolic compounds likely responsible for its effects.

Conclusion: HDE may protect against HCD-induced metabolic disorders and tissues alteration in P. obesus.

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.