年轻男性系统性红斑狼疮伴嗜血球性淋巴组织细胞增多症：诊断挑战。

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

Annals of African Medicine Pub Date : 2025-08-20 DOI:10.4103/aam.aam_172_25

Prakash Shende, Tejas Anil Kore, Vivek Lapsiwala, Pranavi Kalakota

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引用次数: 0

摘要

摘要：系统性红斑狼疮（SLE）很少表现为噬血细胞性淋巴组织细胞增多症（HLH），这是一种严重的高炎症状态，如果不被发现，死亡率很高。我们报告一位21岁的男性，他表现为发烧、腹水、胸腔积液、贫血和急性肾损伤。排除了感染原因，自身免疫标记证实SLE。骨髓活检显示噬血细胞增多，符合HLH-2004的HLH标准。患者对皮质类固醇和羟氯喹反应良好，并计划进行环磷酰胺和肾活检。本病例强调了在系统性炎症和细胞减少的SLE患者中早期识别巨噬细胞激活综合征的重要性。

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Systemic Lupus Erythematosus with Hemophagocytic Lymphohistiocytosis Mimicking Tuberculosis in a Young Male: A Diagnostic Challenge.

Abstract: Systemic lupus erythematosus (SLE) can rarely present with hemophagocytic lymphohistiocytosis (HLH), a severe hyperinflammatory state with high mortality if unrecognized. We report a 21-year-old male who presented with fever, ascites, pleural effusion, anemia, and acute kidney injury. Infectious causes were ruled out, and autoimmune markers confirmed SLE. Bone marrow biopsy showed hemophagocytosis, fulfilling HLH-2004 criteria for HLH. The patient responded well to corticosteroids and hydroxychloroquine, with plans for cyclophosphamide and renal biopsy. This case emphasizes the importance of early recognition of macrophage activation syndrome in SLE patients with systemic inflammation and cytopenias.

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来源期刊

Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

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0.00%

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期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.