黄多酚通过激活秀丽隐杆线虫的自噬和DAF-16表达来防止衰老和神经元损伤。

IF 3.2 2区 生物学 Q3 CELL BIOLOGY
Animal Cells and Systems Pub Date : 2025-08-22 eCollection Date: 2025-01-01 DOI:10.1080/19768354.2025.2549756
Hyemin Kim, Saebyeol Lee, Hak Kyun Kim, Sang-Kyu Park
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引用次数: 0

摘要

黄多酚是一种植物源性植物化学物质,具有抗菌、抗真菌和抗癌活性。我们打算研究黄多酚对氧化应激、衰老和帕金森病反应的影响。以秀丽隐杆线虫为模型系统,在体内研究了日粮中添加黄氧基碱对应激反应和衰老的影响。利用突变体、RNAi和定量RT-PCR进行遗传分析,以确定叶黄素诱导长寿的潜在机制。采用动物疾病模型研究黄多酚对帕金森病的治疗作用。黄多酚增强了对H2O2诱导的氧化应激的抗性。添加黄多酚可显著提高线虫的平均寿命。黄多酚的延长寿命活性并不伴随着生育力的降低。黄多酚延缓了与年龄相关的运动能力下降。有趣的是,两种长寿基因hsp-16.2和sod-3的表达在补充黄多酚后增加。遗传分析表明,黄多酚延长寿命是通过激活自噬和DAF-16介导的。在帕金森病模型中,通过补充黄多酚,以依赖DAF-16的方式防止多巴胺能神经元的退化。综上所述,我们得出结论,黄多酚具有抗衰老活性,可能是通过激活DAF-16依赖性应激反应,并以DAF-16介导的方式降低帕金森病的风险。Xanthoxyline显示了开发抗衰老和帕金森病的新型营养药品的希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression in <i>Caenorhabditis elegans</i>.

Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression in <i>Caenorhabditis elegans</i>.

Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression in <i>Caenorhabditis elegans</i>.

Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression in Caenorhabditis elegans.

Xanthoxyline, a plant-derived phytochemical, has anti-bacterial, anti-fungal, and anti-cancer activities. We intended to investigate the effect of xanthoxyline on the response to oxidative stress, aging, and Parkinson's disease. The effects of dietary supplementation with xanthoxyline on stress response and aging were examined in vivo using Caenorhabditis elegans as a model system. Genetic analysis using mutants, RNAi, and quantitative RT-PCR was performed to identify underlying mechanism involved in xanthoxyline-induced longevity. Animal disease models were employed to examine the effect of xanthoxyline on Parkinson's disease. Xanthoxyline increased resistance to the oxidative stress induced by H2O2. The mean lifespan of worms was significantly increased by supplementation with xanthoxyline. The lifespan-extending activity of xanthoxyline was not accompanied by reduced fertility. Xanthoxyline delayed the age-related decline in motility. Interestingly, the expression of two longevity-assuring genes, hsp-16.2, and sod-3, was increased by xanthoxyline supplementation. Genetic analysis suggested that lifespan extension by xanthoxyline was mediated by activation of autophagy and required DAF-16. In a model of Parkinson's disease, degeneration of dopaminergic neurons was prevented by supplementation with xanthoxyline, in a manner dependent on DAF-16. Taken together, we concluded that xanthoxyline exerts an anti-aging activity, possibly by activating the DAF-16-dependent stress response, and reduces the risk of Parkinson's disease, in a manner mediated by DAF-16. Xanthoxyline shows promise for the development of novel nutraceuticals against aging and Parkinson's disease.

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来源期刊
Animal Cells and Systems
Animal Cells and Systems 生物-动物学
CiteScore
4.50
自引率
24.10%
发文量
33
审稿时长
6 months
期刊介绍: Animal Cells and Systems is the official journal of the Korean Society for Integrative Biology. This international, peer-reviewed journal publishes original papers that cover diverse aspects of biological sciences including Bioinformatics and Systems Biology, Developmental Biology, Evolution and Systematic Biology, Population Biology, & Animal Behaviour, Molecular and Cellular Biology, Neurobiology and Immunology, and Translational Medicine.
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