Ruijia Chen, Harold Lee, Jingxuan Wang, Yulin Yang, Sakurako S Okuzono, Kristen Nishimi, Lindsay Kobayashi, M Maria Glymour, Laura D Kubzansky
{"title":"关键社会暴露成分与认知衰老的独立和联合关联:通过跨国数据的三角测量证据。","authors":"Ruijia Chen, Harold Lee, Jingxuan Wang, Yulin Yang, Sakurako S Okuzono, Kristen Nishimi, Lindsay Kobayashi, M Maria Glymour, Laura D Kubzansky","doi":"10.1093/aje/kwaf189","DOIUrl":null,"url":null,"abstract":"<p><p>We examined the independent and joint associations of five key social exposome components, including financial strain, neighborhood disorder, perceived discrimination, social strain, and traumatic life events, with cognitive function levels and decline. Data were from adults aged > 50 in the US Health and Retirement Study (HRS; n=13,795; 2008-2020) and the English Longitudinal Study of Ageing (ELSA; n=9,469; 2006-2019), and adults aged ≥ 65 in their Harmonized Cognitive Assessment Protocol (HCAP) subsamples (HRS-HCAP: n=2,749; 2016; ELSA-HCAP: n=955; 2018). Using linear mixed-effects models and quantile-based g-computation, we found that all components, except traumatic life events, were associated with lower cognitive function. Simultaneously lowering all components by one quartile could improve cognitive function by 0.09 SD units (95% CI: 0.07-0.11) in the HRS, 0.13 SD units (95% CI: 0.10-0.16) in the ELSA, and 0.07 SD units (95% CI: 0.02-0.13) in the HRS-HCAP. Neighborhood disorder had the strongest negative association with cognitive function in the U.S., while financial strain had the strongest association in England. No social exposome components were associated with faster cognitive decline. The associations of key social exposome components with cognitive function were consistent across countries, although the magnitude of the joint association was greater in England.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Independent and Joint Associations of Key Social Exposome Components with Cognitive Aging: Triangulating Evidence Through Cross-National Data.\",\"authors\":\"Ruijia Chen, Harold Lee, Jingxuan Wang, Yulin Yang, Sakurako S Okuzono, Kristen Nishimi, Lindsay Kobayashi, M Maria Glymour, Laura D Kubzansky\",\"doi\":\"10.1093/aje/kwaf189\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We examined the independent and joint associations of five key social exposome components, including financial strain, neighborhood disorder, perceived discrimination, social strain, and traumatic life events, with cognitive function levels and decline. Data were from adults aged > 50 in the US Health and Retirement Study (HRS; n=13,795; 2008-2020) and the English Longitudinal Study of Ageing (ELSA; n=9,469; 2006-2019), and adults aged ≥ 65 in their Harmonized Cognitive Assessment Protocol (HCAP) subsamples (HRS-HCAP: n=2,749; 2016; ELSA-HCAP: n=955; 2018). Using linear mixed-effects models and quantile-based g-computation, we found that all components, except traumatic life events, were associated with lower cognitive function. Simultaneously lowering all components by one quartile could improve cognitive function by 0.09 SD units (95% CI: 0.07-0.11) in the HRS, 0.13 SD units (95% CI: 0.10-0.16) in the ELSA, and 0.07 SD units (95% CI: 0.02-0.13) in the HRS-HCAP. Neighborhood disorder had the strongest negative association with cognitive function in the U.S., while financial strain had the strongest association in England. No social exposome components were associated with faster cognitive decline. The associations of key social exposome components with cognitive function were consistent across countries, although the magnitude of the joint association was greater in England.</p>\",\"PeriodicalId\":7472,\"journal\":{\"name\":\"American journal of epidemiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of epidemiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/aje/kwaf189\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of epidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/aje/kwaf189","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Independent and Joint Associations of Key Social Exposome Components with Cognitive Aging: Triangulating Evidence Through Cross-National Data.
We examined the independent and joint associations of five key social exposome components, including financial strain, neighborhood disorder, perceived discrimination, social strain, and traumatic life events, with cognitive function levels and decline. Data were from adults aged > 50 in the US Health and Retirement Study (HRS; n=13,795; 2008-2020) and the English Longitudinal Study of Ageing (ELSA; n=9,469; 2006-2019), and adults aged ≥ 65 in their Harmonized Cognitive Assessment Protocol (HCAP) subsamples (HRS-HCAP: n=2,749; 2016; ELSA-HCAP: n=955; 2018). Using linear mixed-effects models and quantile-based g-computation, we found that all components, except traumatic life events, were associated with lower cognitive function. Simultaneously lowering all components by one quartile could improve cognitive function by 0.09 SD units (95% CI: 0.07-0.11) in the HRS, 0.13 SD units (95% CI: 0.10-0.16) in the ELSA, and 0.07 SD units (95% CI: 0.02-0.13) in the HRS-HCAP. Neighborhood disorder had the strongest negative association with cognitive function in the U.S., while financial strain had the strongest association in England. No social exposome components were associated with faster cognitive decline. The associations of key social exposome components with cognitive function were consistent across countries, although the magnitude of the joint association was greater in England.
期刊介绍:
The American Journal of Epidemiology is the oldest and one of the premier epidemiologic journals devoted to the publication of empirical research findings, opinion pieces, and methodological developments in the field of epidemiologic research.
It is a peer-reviewed journal aimed at both fellow epidemiologists and those who use epidemiologic data, including public health workers and clinicians.