Jung Ki Kim, Masroor Anwar, Abhishek Gupta, Bharat Thyagarajan, Peifeng Hu, Jessica D Faul, David R Weir, Kenneth M Langa, Jinkook Lee, Sharmistha Dey, Eileen M Crimmins
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引用次数: 0
摘要
本研究在印度和美国老年人的全国代表性样本中研究了基于血液的神经退行性生物标志物与认知功能之间的关系。利用印度纵向衰老研究的数据，痴呆诊断评估（LASI-DAD）和健康与退休研究（HRS），我们分析了四种生物标志物-淀粉样蛋白β42与β40的比值（Aβ42/Aβ40），胶质纤维酸性蛋白（GFAP），神经丝轻链（NfL）和苏氨酸181磷酸化Tau (pTau181)-与认知结果的关系。在这两个人群中，较高水平的GFAP和NfL与更差的认知功能和更大的痴呆可能性相关。GFAP和NfL也与HRS的认知能力下降有关，但与LASI-DAD无关。a - β42/ a - β40比值越高，HRS患者认知功能越差，痴呆越多；另一方面，较高水平的a - β42/ a - β40比值与LASI-DAD患者更好的认知功能显著相关。在这两个国家，PTau181通常与认知功能无关。这些发现表明，这些生物标志物，特别是GFAP和NfL，在澄清与认知能力下降和痴呆的关系方面有一定的前景。整套标记与随后死亡率的关联表明，它们可能作为一般衰老的标记。
Association of Blood-based Neurodegenerative Biomarkers with cognitive functioning and dementia in India (LASI-DAD) and the United States (HRS).
This study examines associations between blood-based neurodegenerative biomarkers and cognitive functioning in nationally representative samples of older adults in India and the United States. Using data from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD) and the Health and Retirement Study (HRS), we analyzed four biomarkers-the ratio of Amyloid beta 42 to 40 (Aβ42/Aβ40), Glial Fibrillary Acidic Protein (GFAP), Neurofilament Light Chain (NfL), and Phosphorylated Tau at Threonine 181 (pTau181)-in relation to cognitive outcomes. Higher levels of GFAP and NfL were associated with worse cognitive function and a greater likelihood of dementia in both populations. GFAP and NfL also were associated with cognitive decline in the HRS, but not in LASI-DAD. Higher Aβ42/Aβ40 ratio was associated with worse cognitive functioning and more dementia in HRS; on the other hand, higher levels of the Aβ42/Aβ40 ratio were significantly linked with better cognitive functioning in LASI-DAD. PTau181 was generally not associated with cognitive functioning in either country. These findings suggest some promise for these biomarkers, especially GFAP and NfL, for clarifying associations with cognitive decline and dementia. The associations of the whole set of markers with subsequent mortality suggest they may serve as markers for general aging.
期刊介绍：
The American Journal of Epidemiology is the oldest and one of the premier epidemiologic journals devoted to the publication of empirical research findings, opinion pieces, and methodological developments in the field of epidemiologic research.
It is a peer-reviewed journal aimed at both fellow epidemiologists and those who use epidemiologic data, including public health workers and clinicians.
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