在美国成年人中,血清α-Klotho水平的降低与定期饮酒和酗酒的水平有关。

IF 2.2 4区 医学 Q3 SUBSTANCE ABUSE
Dylan Fromm, Jianmin Zhu, Wonjun Billy Kim, Yudan Wei
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引用次数: 0

摘要

目的:饮酒与许多有害的健康结果和与衰老有关的疾病有关。本研究旨在探讨饮酒水平和饮酒行为对中老年人血清Klotho蛋白水平的影响,Klotho蛋白是一种健康和长寿的抗衰老生物标志物。方法:采用多元一般线性模型对2013-2016年全国健康与营养调查中具有全国代表性的4225名40-79岁成年人进行分析。根据国家指南,饮酒水平分为轻度(男性每天饮酒≤2杯,女性每天饮酒≤1杯)、中度(男性3-4杯,女性2-3杯)和重度饮酒(男性≥5杯,女性≥4杯)。结果:不同饮酒水平的人群血清中* * -Klotho水平均显著降低,且呈剂量依赖性,加权几何均值分别为798.80 (P = 0.0238)、774.75 (P = 0.0006)、751.83 (P = 0.0027)和744.33 pg/ml (P)。结论:本研究表明,中老年人饮酒与血清中* * -Klotho水平呈显著负相关。需要进一步的研究来阐明降低Klotho水平在酒精诱导的健康和衰老疾病中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decreases in serum α-Klotho levels in association with levels of regular alcohol drinking and binge drinking among US adults.

Aims: Alcohol consumption is associated with numerous detrimental health outcomes and aging-related disorders. This study aims to investigate the impact of alcohol drinking levels and drinking behavior on serum levels of Klotho protein, an anti-aging biomarker for health and longevity, in middle-aged and older adults.

Methods: A nationally representative sample of 4225 adults aged 40-79 years from the 2013-2016 National Health and Nutrition Examination Surveys were analyzed using multiple general linear models. Drinking levels were classified as light (consumed ≤ 2 drinks for men and ≤ 1 drink for women in a day), moderate (3-4 for men and 2-3 drinks for women), and heavy drinking (≥ 5 for men and ≥ 4 drinks for women), according to national guidelines.

Results: Significantly decreased serum ɑ-Klotho levels were found in all levels of drinking in a dose-dependent manner, with weighted geometric means of 798.80 (P = .0238), 774.75 (P = .0006), 751.83 (P = .0027), and 744.33 pg/ml (P < .0001) in light, moderate, heavy, and former heavy drinkers, respectively, compared to non-drinkers (827.69 pg/ml). After adjusting for covariates, moderate drinking was associated with a 6.53% (P < .0001) decrease, heavy drinking with an 8.97% (P = .0004) decrease, and former heavy drinking with an 7.26% (P < .0001) decrease in ɑ-Klotho levels. Similarly, binge drinking ≥ 4 days in the past month was associated with a 9.17% (P = .0341) decrease in serum ɑ-Klotho.

Conclusions: This study demonstrates a significantly inverse relationship between alcohol consumption and serum ɑ-Klotho levels in middle-aged and older adults. Further studies are warranted to elucidate the role of reducing Klotho levels in alcohol-induced health and aging disorders.

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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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