肌肉营养不良。

4区 医学 Q2 Biochemistry, Genetics and Molecular Biology
Yi-Wen Chen, Adam J Bittel, Daniel C Bittel, Young Jae Moon, Nikki M McCormack, Jyoti K Jaiswal
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引用次数: 0

摘要

骨骼肌重塑和再生,以响应生理和病理条件。肌肉疾病可能是由分子和细胞通路的紊乱引起的,这些通路对维持肌肉在生理刺激和环境挑战下的稳态很重要。肌肉萎缩症是一组罕见的进行性疾病,涉及肌肉变性和再生,再生缺陷和失败导致肌肉损失和功能下降。目前,这些疾病无法治愈,尽管许多治疗方法正在开发中。在本章中,我们讨论了最常见的肌肉营养不良症的遗传原因、疾病机制和治疗进展,包括杜氏肌营养不良症(DMD)、肌强直性营养不良症(MD)、面肩肱肌营养不良症(FSHD)和肢带肌营养不良症(LGMD)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Muscular Dystrophies.

Skeletal muscles remodel and regenerate in response to physiological and pathological conditions. Muscle disorders can be caused by disturbance of molecular and cellular pathways that are important in maintaining muscle homeostasis in response to physiological stimuli and environmental challenges. Muscular dystrophies are a heterogeneous group of rare, progressive diseases involving muscle degeneration and regeneration, with defects and failure in regeneration contributing to muscle loss and functional decline. Currently, there is no cure for these diseases, although many therapeutic approaches are in development. In this chapter, we discuss genetic causes, disease mechanisms, and therapeutic development for the most common muscular dystrophies, including Duchenne muscular dystrophy (DMD), myotonic dystrophy (MD) facioscapulohumeral muscular dystrophy (FSHD), and limb-girdle muscular dystrophies (LGMD).

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来源期刊
Advances in experimental medicine and biology
Advances in experimental medicine and biology 医学-医学:研究与实验
CiteScore
5.90
自引率
0.00%
发文量
465
审稿时长
2-4 weeks
期刊介绍: Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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