从布纳肯国家公园的海绵中分离出的Aaptos sp，促进结直肠癌细胞周期阻滞和诱导坏死细胞死亡。

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Acta Chimica Slovenica Pub Date : 2024-12-02 DOI:10.17344/acsi.2024.8779

Annisa Elcentia Fajarwati, Mutia Hardhiyuna, Febby Nurdiya Ningsih, Adam Hermawan, Dyaningtyas Dewi Pamungkas Putri, Nurul Fatimah, Asep Bayu, Andi Setiawan, Ucu Yanu Arbi, Tutik Murniasih, A'liyatur Rosyidah, Tri Aryono Hadi, Masteria Yunovilsa Putra, Peni Ahmadi

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引用次数: 0

摘要

海绵是生物活性化合物的潜在来源之一。其中，海绵Aaptos已成为包括aaptamine在内的主要药物的有希望的发现(1)。本研究研究了从印度尼西亚Bunaken国家公园收集的Aaptos sp.中光谱测定的aaptamine(1)，作为一种抗癌剂，专门针对结直肠癌（crc）。化合物1对DLD-1和Caco-2具有较强的细胞毒性，IC50值分别为30.3和236.8µg/mL。此外，化合物1暴露于结直肠癌细胞可促进细胞周期阻滞，相对诱导坏死细胞死亡。

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Aaptamine, Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers, Isolated from the Bunaken National Park's Sponge, Aaptos sp.

The sponge is one of the potential sources of bioactive compounds. Among them, the sponge Aaptos has been a promising discovery of leading drugs including aaptamine (1). This study investigated the aaptamine (1), spectroscopically determined, from Aaptos sp. collected from Bunaken National Park, Indonesia, as an anticancer agent, specifically targeting colorectal cancers (CRCs). Compound 1 showed potent cytotoxicity against DLD-1 and Caco-2 with IC50 values of 30.3 and 236.8 µg/mL, respectively. In addition, the exposure of compound 1 on those colorectal cancer cells could promote cell cycle arrest and relatively induce necrotic cell death.

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来源期刊

Acta Chimica Slovenica 化学-化学综合

CiteScore

2.50

自引率

25.00%

发文量

审稿时长

1.0 months

期刊介绍： Is an international, peer-reviewed and Open Access journal. It provides a forum for the publication of original scientific research in all fields of chemistry and closely related areas. Reviews, feature, scientific and technical articles, and short communications are welcome.