环状rna与rna结合蛋白结合。

4区 医学 Q2 Biochemistry, Genetics and Molecular Biology
Mandakini Singh, Kirthik Roshan, Srinivasan Muthuswamy, Ajay Kumar, Santosh Kumar
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引用次数: 0

摘要

高通量RNA测序产生称为环状RNA (circRNAs)的新型非编码RNA。它们广泛分布在人类和其他后生动物的转录组中。研究表明,它们在多种细胞发育过程和疾病中具有重要作用,包括癌症、认知障碍和神经退行性疾病(ndd)。除此之外,circRNAs通过与每种细胞类型独特的rna结合蛋白(rbp)结合来执行细胞功能。rbp是一个庞大的蛋白质家族,通过稳定、定位、剪接、核输出和RNA翻译等多种过程调节基因表达。近年来,circRNA和RBP复合物对circRNA合成的影响变得更加明显。根据新的发现,环状rna与rbp相互作用,并改变其他rna和蛋白质的运作方式。许多疾病也与这些关系有关。正因为如此,关于circRNA和RBP关系的研究对于理解许多疾病的起源至关重要。本章描述了新发现的circRNAs和rbp之间相互作用的机制,以及它们在疾病和生物过程中的功能意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circular RNAs Binding to RNA-Binding Proteins.

High-throughput RNA sequencing yields novel noncoding RNAs called circular RNAs (circRNAs). They are extensively distributed across the transcriptomes of humans and other metazoans. Research has demonstrated their critical functions in multiple cellular developmental processes and diseases, including cancer, cognitive disorders, and neurodegenerative disorders (NDDs). Aside from this, circRNAs carry out cellular functions by associating with RNA-binding proteins (RBPs) that are unique for each cell type. Given that they are a vast family of proteins, RBPs regulate gene expression through various processes like stabilization, localization, splicing, nuclear export, and RNA translation. The impact of circRNAs and the RBP complex on circRNA synthesis has become more apparent in recent years. As per new findings, circRNAs interact with RBPs and modify the way in which other RNAs and proteins operate. Numerous diseases are also linked to these relationships. Because of this, research regarding the circRNA and RBP relationship is crucial to comprehend the origins of a number of disorders. This chapter describes the newly discovered mechanisms underlying the interactions between circRNAs and RBPs as well as their functional significance in both illnesses and biological processes.

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来源期刊
Advances in experimental medicine and biology
Advances in experimental medicine and biology 医学-医学:研究与实验
CiteScore
5.90
自引率
0.00%
发文量
465
审稿时长
2-4 weeks
期刊介绍: Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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