lncRNA EBLN3P通过miR-141-3p/HMGCS1促进胃癌细胞增殖、转移和干性

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Genetics Pub Date : 2025-08-25 DOI:10.1007/s10528-025-11235-8

Yang Zong, Jia Shen, Lei Wang, Lifeng Wang, Yuli Chen, Chenxing Ge, Jianfeng Gu, Qi Hu

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引用次数: 0

摘要

长链非编码rna （lncRNAs）已成为胃癌发生和转移的重要因素。本研究旨在揭示EBLN3P在胃癌中的功能意义。GC组EBLN3P和HMGCS1明显升高。相反，miR-141-3p降低。定位分析显示EBLN3P主要定位于细胞质而非细胞核。在MKN28和SGC7901细胞中，EBLN3P敲低抑制了细胞的增殖、转移和干细胞性。相反，过表达EBLN3P促进了这些细胞过程。EBLN3P/miR-141-3p/HMGCS1轴在GC进展中起关键作用。

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lncRNA EBLN3P Promotes Proliferation, Metastasis and Stemness of Gastric Cancer Cells via miR-141-3p/HMGCS1.

Long non-coding RNAs (lncRNAs) have become an essential factor in gastric cancer (GC) initiation and metastasis. This study is aimed to uncover the functional significance of EBLN3P in GC. In GC, EBLN3P and HMGCS1 was significantly increased. In contrast, miR-141-3p was decreased. Localization assay revealed that EBLN3P primarily localized in the cytoplasm rather than the nucleus. In MKN28 and SGC7901 cells, EBLN3P knockdown suppressed cell proliferation, metastasis and stemness. On the contrary, overexpression of EBLN3P facilitated these cellular processes. The EBLN3P/miR-141-3p/HMGCS1 axis was identified to play crucial functions in GC progression.

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来源期刊

Biochemical Genetics 生物-生化与分子生物学

CiteScore

3.90

自引率

0.00%

发文量

133

审稿时长

4.8 months

期刊介绍： Biochemical Genetics welcomes original manuscripts that address and test clear scientific hypotheses, are directed to a broad scientific audience, and clearly contribute to the advancement of the field through the use of sound sampling or experimental design, reliable analytical methodologies and robust statistical analyses. Although studies focusing on particular regions and target organisms are welcome, it is not the journal’s goal to publish essentially descriptive studies that provide results with narrow applicability, or are based on very small samples or pseudoreplication. Rather, Biochemical Genetics welcomes review articles that go beyond summarizing previous publications and create added value through the systematic analysis and critique of the current state of knowledge or by conducting meta-analyses. Methodological articles are also within the scope of Biological Genetics, particularly when new laboratory techniques or computational approaches are fully described and thoroughly compared with the existing benchmark methods. Biochemical Genetics welcomes articles on the following topics: Genomics; Proteomics; Population genetics; Phylogenetics; Metagenomics; Microbial genetics; Genetics and evolution of wild and cultivated plants; Animal genetics and evolution; Human genetics and evolution; Genetic disorders; Genetic markers of diseases; Gene technology and therapy; Experimental and analytical methods; Statistical and computational methods.