Judith Desmet, Maria A. Aretaki, Mar Viana, Ethel Eljarrat
{"title":"对空气样本中经典的和新兴的阻燃剂和增塑剂的采样、保存和分析策略的发展。","authors":"Judith Desmet, Maria A. Aretaki, Mar Viana, Ethel Eljarrat","doi":"10.1007/s00216-025-06057-x","DOIUrl":null,"url":null,"abstract":"<div><p>This study presents a methodology for sampling, preserving, and analyzing 15 organophosphate esters (OPEs), 11 phthalate esters (PEs), and 6 alternative plasticizers (APs) in indoor air. Accurate quantification is essential, given their widespread use in household items and adverse health effects associated with exposure. Solid-phase extraction (SPE) cartridges, collecting both gaseous and particulate phases, connected to a low-volume pump were used for the collection of air samples. Stability tests confirm that storing samples at 4 °C is most optimal to maintain analyte integrity for at least 2 weeks. The analytes were extracted and then purified online using turbulent flow chromatography, before analysis via liquid chromatography-tandem mass spectrometry (TFC-LC–MS/MS). Quantification was carried out by applying the isotopic dilution method with labelled standards. Recoveries ranged from 50 to 136%, with reproducibility below 21%. The relative standard deviation (RSD) varied from 2 to 31%, only exceeding the 20% threshold for certain OPEs at lower concentrations. Limits of detection (mLODs) varied between 0.02–0.89 ng/m<sup>3</sup>, 0.02–20.0 ng/m<sup>3</sup>, and 0.07–1.47 ng/m<sup>3</sup> for OPEs, PEs, and APs, respectively. The study demonstrates that this methodology is effective, cost-efficient, and suitable for monitoring a total of 33 flame retardants and plasticizers in indoor air. It minimizes material costs and sample handling time by allowing direct analysis without pretreatment. Results from indoor air samples collected in a case study revealed that OPEs attributed to less than 20% of the chemical profile, while triethyl citrate (TEC) was detected at concentrations up to 28.9 ng/m<sup>3</sup>, confirming the method’s applicability for the added APs.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":"417 23","pages":"5335 - 5347"},"PeriodicalIF":3.8000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432039/pdf/","citationCount":"0","resultStr":"{\"title\":\"Development of a strategy for sampling, preservation, and analysis of classical and emerging flame retardants and plasticizers in air samples\",\"authors\":\"Judith Desmet, Maria A. 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Quantification was carried out by applying the isotopic dilution method with labelled standards. Recoveries ranged from 50 to 136%, with reproducibility below 21%. The relative standard deviation (RSD) varied from 2 to 31%, only exceeding the 20% threshold for certain OPEs at lower concentrations. Limits of detection (mLODs) varied between 0.02–0.89 ng/m<sup>3</sup>, 0.02–20.0 ng/m<sup>3</sup>, and 0.07–1.47 ng/m<sup>3</sup> for OPEs, PEs, and APs, respectively. The study demonstrates that this methodology is effective, cost-efficient, and suitable for monitoring a total of 33 flame retardants and plasticizers in indoor air. It minimizes material costs and sample handling time by allowing direct analysis without pretreatment. Results from indoor air samples collected in a case study revealed that OPEs attributed to less than 20% of the chemical profile, while triethyl citrate (TEC) was detected at concentrations up to 28.9 ng/m<sup>3</sup>, confirming the method’s applicability for the added APs.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":462,\"journal\":{\"name\":\"Analytical and Bioanalytical Chemistry\",\"volume\":\"417 23\",\"pages\":\"5335 - 5347\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432039/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analytical and Bioanalytical Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00216-025-06057-x\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and Bioanalytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00216-025-06057-x","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Development of a strategy for sampling, preservation, and analysis of classical and emerging flame retardants and plasticizers in air samples
This study presents a methodology for sampling, preserving, and analyzing 15 organophosphate esters (OPEs), 11 phthalate esters (PEs), and 6 alternative plasticizers (APs) in indoor air. Accurate quantification is essential, given their widespread use in household items and adverse health effects associated with exposure. Solid-phase extraction (SPE) cartridges, collecting both gaseous and particulate phases, connected to a low-volume pump were used for the collection of air samples. Stability tests confirm that storing samples at 4 °C is most optimal to maintain analyte integrity for at least 2 weeks. The analytes were extracted and then purified online using turbulent flow chromatography, before analysis via liquid chromatography-tandem mass spectrometry (TFC-LC–MS/MS). Quantification was carried out by applying the isotopic dilution method with labelled standards. Recoveries ranged from 50 to 136%, with reproducibility below 21%. The relative standard deviation (RSD) varied from 2 to 31%, only exceeding the 20% threshold for certain OPEs at lower concentrations. Limits of detection (mLODs) varied between 0.02–0.89 ng/m3, 0.02–20.0 ng/m3, and 0.07–1.47 ng/m3 for OPEs, PEs, and APs, respectively. The study demonstrates that this methodology is effective, cost-efficient, and suitable for monitoring a total of 33 flame retardants and plasticizers in indoor air. It minimizes material costs and sample handling time by allowing direct analysis without pretreatment. Results from indoor air samples collected in a case study revealed that OPEs attributed to less than 20% of the chemical profile, while triethyl citrate (TEC) was detected at concentrations up to 28.9 ng/m3, confirming the method’s applicability for the added APs.
期刊介绍:
Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.