利用质谱分析解决血管基质中大麻素分析挑战的分析方法。

IF 6.6 2区 化学 Q1 SPECTROSCOPY
Radwa Mahmoud, Robert B Laprairie, Anas El-Aneed
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引用次数: 0

摘要

植物大麻素是从大麻植物中提取的生物活性代谢物。由于其娱乐用途和治疗潜力,它们引起了人们的注意。虽然各种分析策略已被用于它们的分析,质谱联用色谱分离是优越的,因为它的灵敏度和选择性。综述了气相色谱(GC-MS)和液相色谱-质谱(LC-MS)等多种基于质谱的方法,重点介绍了血管基质中植物大麻素的分析。包括血浆、血清、全血和干血斑(DBS)。每个MS策略在血管基质中的应用,优势和挑战进行了评估和批判性讨论。此外,该综述概述了DBS斑点分析的挑战,例如血细胞比容偏差,与血浆/血清和全血处理相比,涉及蛋白质去除,提取和清理步骤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry.

Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity and selectivity. Various MS-based strategies, namely Gas chromatography (GC-MS) and liquid chromatography - MS (LC-MS) are reviewed with focus on the analysis of phytocannabinoids in vascular matrices. These include plasma, serum, whole blood, and dried blood spots (DBS). Applications, advantages and challenges associated with each MS strategy in vascular matrices are evaluated and critically discussed. In addition, the review outlines the challenges in DBS spot analysis, such as hematocrit bias, versus plasma/serum and whole blood processing, which involves protein removal, extraction and cleanup steps.

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来源期刊
Mass Spectrometry Reviews
Mass Spectrometry Reviews 物理-光谱学
CiteScore
16.30
自引率
3.00%
发文量
56
期刊介绍: The aim of the journal Mass Spectrometry Reviews is to publish well-written reviews in selected topics in the various sub-fields of mass spectrometry as a means to summarize the research that has been performed in that area, to focus attention of other researchers, to critically review the published material, and to stimulate further research in that area. The scope of the published reviews include, but are not limited to topics, such as theoretical treatments, instrumental design, ionization methods, analyzers, detectors, application to the qualitative and quantitative analysis of various compounds or elements, basic ion chemistry and structure studies, ion energetic studies, and studies on biomolecules, polymers, etc.
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