Pirkko Kriikku, Anna Pelander, Antti Jylhä, Ilkka Ojanperä
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Post-Mortem Identification and Toxicological Findings of Fluetonitazepyne and Isotonitazepyne.
Nitazepyne-type substances, such as fluetonitazepyne and isotonitazepyne, are among the latest additions to the group of nitazenes-highly potent and dangerous opioids that have emerged on the illicit drug market in recent years. In early 2025, five death cases in Finland tested positive for fluetonitazepyne and one for isotonitazepyne in urine drug screening. The median (range) concentration of fluetonitazepyne in post-mortem femoral blood was 1.7 (0.4-9.5) μg/L, and the concentration of isotonitazepyne was 1.4 μg/L. Other psychoactive substances were detected in all cases. A peak corresponding to O-dealkylated fluetonitazepyne, the 4-OH-nitazepyne metabolite, was present in all fluetonitazepyne-positive urine samples and was later used in the identification of isotonitazepyne in one fatal case. This metabolite proved useful as a marker compound for nitazepyne-type benzimidazole opioids in a urine screening.
期刊介绍：
As the incidence of drugs escalates in 21st century living, their detection and analysis have become increasingly important. Sport, the workplace, crime investigation, homeland security, the pharmaceutical industry and the environment are just some of the high profile arenas in which analytical testing has provided an important investigative tool for uncovering the presence of extraneous substances.
In addition to the usual publishing fare of primary research articles, case reports and letters, Drug Testing and Analysis offers a unique combination of; ‘How to’ material such as ‘Tutorials’ and ‘Reviews’, Speculative pieces (‘Commentaries’ and ‘Perspectives'', providing a broader scientific and social context to the aspects of analytical testing), ‘Annual banned substance reviews’ (delivering a critical evaluation of the methods used in the characterization of established and newly outlawed compounds).
Rather than focus on the application of a single technique, Drug Testing and Analysis employs a unique multidisciplinary approach to the field of controversial compound determination. Papers discussing chromatography, mass spectrometry, immunological approaches, 1D/2D gel electrophoresis, to name just a few select methods, are welcomed where their application is related to any of the six key topics listed below.
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