男性生殖器上皮和肛管的序列HPV16变异感染。

IF 4.7 2区医学 Q1 ONCOLOGY

International Journal of Cancer Pub Date : 2025-08-28 DOI:10.1002/ijc.70111

Racheal S Dube Mandishora, Milena Giulia Gonçalves, Wenyi Fan, Bradley Sirak, Matthew Thomas Ferreira, Richard R Reich, Kimberly Isaacs-Soriano, Martha Abrahamsen, Eduardo Lazcano Ponce, Luisa L Villa, Anna R Giuliano, Laura Sichero

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引用次数: 0

摘要

本研究旨在利用来自男性HPV感染（HIM）研究队列的数据，评估美国和拉丁美洲男性生殖器和肛门部位的HPV16变异期患病率和顺序获得性。在635名生殖器HPV16患者和115名肛门HPV16患者中，53名男性在两个部位均检测出HPV16变异阳性，HPV16 A1在两个部位最普遍，在肛管中更为普遍。依次获得hpv16a1的比例分别为30.4%（生殖器到肛门）和29.4%（肛门到生殖器）。这些发现为HPV16在男性解剖部位的变异分布提供了见解。

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Sequential HPV16 variant infections in the genital epithelium and anal canal of men.

This study aimed to assess HPV16 variant period prevalence and sequential acquisition at genital and anal sites in men from the USA and Latin America, using data from the HPV Infection in Men (HIM) Study cohort. Among 635 men with genital and 115 with anal HPV16, 53 men tested positive for any HPV16 variant at both sites, and HPV16 A1 was most prevalent at both sites, more so at the anal canal. Sequential acquisition of HPV16 A1 occurred in 30.4% (genital to anal) and 29.4% (anal to genital). These findings offer insight into HPV16 variant distribution across anatomic sites in men.

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来源期刊

International Journal of Cancer 医学-肿瘤学

CiteScore

13.40

自引率

3.10%

发文量

460

审稿时长

2 months

期刊介绍： The International Journal of Cancer (IJC) is the official journal of the Union for International Cancer Control—UICC; it appears twice a month. IJC invites submission of manuscripts under a broad scope of topics relevant to experimental and clinical cancer research and publishes original Research Articles and Short Reports under the following categories: -Cancer Epidemiology- Cancer Genetics and Epigenetics- Infectious Causes of Cancer- Innovative Tools and Methods- Molecular Cancer Biology- Tumor Immunology and Microenvironment- Tumor Markers and Signatures- Cancer Therapy and Prevention