在60天的卧床休息中,人工重力可以保护骨骼并防止骨髓脂肪组织的积累。

IF 5.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
K Culliton, G Melkus, A Sheikh, T Liu, A Berthiaume, G Armbrecht, G Trudel
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引用次数: 0

摘要

不运动与骨髓脂肪组织(BMAT)增加和骨质流失有关。人工重力(AG)可以预防这些并发症。这项随机对照试验研究了足部2g AG预防腰椎BMAT积累和骨质流失的有效性。24名参与者(16名男性,8名女性)头部向下倾斜6°卧床60天。他们被随机分配到仅卧床(n=8)、连续仰卧离心(cAG, 30分钟/天)或间歇仰卧离心(iAG, 6次,5分钟/天)。连续3T磁共振(MR)测量BMAT,双能x线骨密度仪测量卧床前、卧床期间和卧床后腰椎骨矿物质密度(BMD)。与cAG和iAG干预相比,卧床60天后,对照组椎体BMAT高于cAG和iAG干预,为+3.93% (95%CI -0.28至8.14)。卧床60天后,男性对照BMAT增加了5.81% (95%CI 2.01 - 9.61),而cAG和iAG男性受试者分别增加了-1.35% (95%CI -5.74 - 3.04)和1.23% (95%CI -1.53 - 3.99)。干预间差异有统计学意义:X2(2)=8.487, p=0.014。此外,对照组男性受试者在卧床60天后骨密度下降(-0.02g/cm2; 95%CI -0.05 ~ 0.00),而接受iAG治疗的男性受试者在卧床期间骨密度没有下降(0.00g/cm2; 95%CI -0.04 ~ 0.05)。BMAT的调节与同一椎骨的骨密度呈负相关。在水平参与者上机械地重建轴向力矢量可以防止BMAT积累和脱矿。这些发现建议探索技术进步,将这些临床益处转化为有急性或慢性骨质流失风险的人群。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 days of bed rest.

Inactivity has been associated with increased bone marrow adipose tissue (BMAT) and bone loss. Artificial gravity (AG) may prevent these complications. This randomized controlled trial investigated the effectiveness of AG at 2g at the feet to prevent lumbar vertebral BMAT accumulation and bone loss. Twenty-four participants (16 male, 8 female) were bedridden for 60 days at 6° head down tilt. They were randomly assigned to bedrest only (n=8), continuous supine centrifugation (cAG; 30 minutes/day), or intermittent supine centrifugation (iAG; 6 bouts of 5 minutes/day). Serial 3T magnetic resonance (MR) measured BMAT while Dual Energy X-ray Absorptiometry measured bone mineral density (BMD) in the lumbar vertebrae before, during, and after bedrest. After 60 days of bedrest, vertebral BMAT was higher in controls, +3.93% (95%CI -0.28 to 8.14), compared to cAG and iAG interventions. After 60 days of bedrest, male controls BMAT increased 5.81% (95%CI 2.01 to 9.61) compared to -1.35% (95%CI -5.74 to 3.04) and 1.23% (95%CI -1.53 to 3.99) for male cAG and iAG participants respectively. This difference between interventions was significant: X2(2)=8.487, p=0.014. In addition, while control male participants showed decreased BMD after 60 days of bedrest (-0.02g/cm2; 95%CI -0.05 to 0.00), the male participants receiving iAG showed no decrease in BMD during bedrest (0.00g/cm2; 95%CI -0.04 to 0.05). The modulation of BMAT was inversely correlated with BMD at the same vertebrae. Recreating an axial force vector mechanically on horizontalized participants prevented BMAT accumulation and demineralization. These findings suggest exploring technological advances to translate these clinical benefits to populations at risk of acute or chronic bone loss.

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来源期刊
Journal of Bone and Mineral Research
Journal of Bone and Mineral Research 医学-内分泌学与代谢
CiteScore
11.30
自引率
6.50%
发文量
257
审稿时长
2 months
期刊介绍: The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
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