K Culliton, G Melkus, A Sheikh, T Liu, A Berthiaume, G Armbrecht, G Trudel
{"title":"在60天的卧床休息中,人工重力可以保护骨骼并防止骨髓脂肪组织的积累。","authors":"K Culliton, G Melkus, A Sheikh, T Liu, A Berthiaume, G Armbrecht, G Trudel","doi":"10.1093/jbmr/zjaf119","DOIUrl":null,"url":null,"abstract":"<p><p>Inactivity has been associated with increased bone marrow adipose tissue (BMAT) and bone loss. Artificial gravity (AG) may prevent these complications. This randomized controlled trial investigated the effectiveness of AG at 2g at the feet to prevent lumbar vertebral BMAT accumulation and bone loss. Twenty-four participants (16 male, 8 female) were bedridden for 60 days at 6° head down tilt. They were randomly assigned to bedrest only (n=8), continuous supine centrifugation (cAG; 30 minutes/day), or intermittent supine centrifugation (iAG; 6 bouts of 5 minutes/day). Serial 3T magnetic resonance (MR) measured BMAT while Dual Energy X-ray Absorptiometry measured bone mineral density (BMD) in the lumbar vertebrae before, during, and after bedrest. After 60 days of bedrest, vertebral BMAT was higher in controls, +3.93% (95%CI -0.28 to 8.14), compared to cAG and iAG interventions. After 60 days of bedrest, male controls BMAT increased 5.81% (95%CI 2.01 to 9.61) compared to -1.35% (95%CI -5.74 to 3.04) and 1.23% (95%CI -1.53 to 3.99) for male cAG and iAG participants respectively. This difference between interventions was significant: X2(2)=8.487, p=0.014. In addition, while control male participants showed decreased BMD after 60 days of bedrest (-0.02g/cm2; 95%CI -0.05 to 0.00), the male participants receiving iAG showed no decrease in BMD during bedrest (0.00g/cm2; 95%CI -0.04 to 0.05). The modulation of BMAT was inversely correlated with BMD at the same vertebrae. Recreating an axial force vector mechanically on horizontalized participants prevented BMAT accumulation and demineralization. These findings suggest exploring technological advances to translate these clinical benefits to populations at risk of acute or chronic bone loss.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.9000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 days of bed rest.\",\"authors\":\"K Culliton, G Melkus, A Sheikh, T Liu, A Berthiaume, G Armbrecht, G Trudel\",\"doi\":\"10.1093/jbmr/zjaf119\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Inactivity has been associated with increased bone marrow adipose tissue (BMAT) and bone loss. Artificial gravity (AG) may prevent these complications. This randomized controlled trial investigated the effectiveness of AG at 2g at the feet to prevent lumbar vertebral BMAT accumulation and bone loss. Twenty-four participants (16 male, 8 female) were bedridden for 60 days at 6° head down tilt. They were randomly assigned to bedrest only (n=8), continuous supine centrifugation (cAG; 30 minutes/day), or intermittent supine centrifugation (iAG; 6 bouts of 5 minutes/day). Serial 3T magnetic resonance (MR) measured BMAT while Dual Energy X-ray Absorptiometry measured bone mineral density (BMD) in the lumbar vertebrae before, during, and after bedrest. After 60 days of bedrest, vertebral BMAT was higher in controls, +3.93% (95%CI -0.28 to 8.14), compared to cAG and iAG interventions. After 60 days of bedrest, male controls BMAT increased 5.81% (95%CI 2.01 to 9.61) compared to -1.35% (95%CI -5.74 to 3.04) and 1.23% (95%CI -1.53 to 3.99) for male cAG and iAG participants respectively. This difference between interventions was significant: X2(2)=8.487, p=0.014. In addition, while control male participants showed decreased BMD after 60 days of bedrest (-0.02g/cm2; 95%CI -0.05 to 0.00), the male participants receiving iAG showed no decrease in BMD during bedrest (0.00g/cm2; 95%CI -0.04 to 0.05). The modulation of BMAT was inversely correlated with BMD at the same vertebrae. Recreating an axial force vector mechanically on horizontalized participants prevented BMAT accumulation and demineralization. These findings suggest exploring technological advances to translate these clinical benefits to populations at risk of acute or chronic bone loss.</p>\",\"PeriodicalId\":185,\"journal\":{\"name\":\"Journal of Bone and Mineral Research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Bone and Mineral Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/jbmr/zjaf119\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bone and Mineral Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jbmr/zjaf119","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 days of bed rest.
Inactivity has been associated with increased bone marrow adipose tissue (BMAT) and bone loss. Artificial gravity (AG) may prevent these complications. This randomized controlled trial investigated the effectiveness of AG at 2g at the feet to prevent lumbar vertebral BMAT accumulation and bone loss. Twenty-four participants (16 male, 8 female) were bedridden for 60 days at 6° head down tilt. They were randomly assigned to bedrest only (n=8), continuous supine centrifugation (cAG; 30 minutes/day), or intermittent supine centrifugation (iAG; 6 bouts of 5 minutes/day). Serial 3T magnetic resonance (MR) measured BMAT while Dual Energy X-ray Absorptiometry measured bone mineral density (BMD) in the lumbar vertebrae before, during, and after bedrest. After 60 days of bedrest, vertebral BMAT was higher in controls, +3.93% (95%CI -0.28 to 8.14), compared to cAG and iAG interventions. After 60 days of bedrest, male controls BMAT increased 5.81% (95%CI 2.01 to 9.61) compared to -1.35% (95%CI -5.74 to 3.04) and 1.23% (95%CI -1.53 to 3.99) for male cAG and iAG participants respectively. This difference between interventions was significant: X2(2)=8.487, p=0.014. In addition, while control male participants showed decreased BMD after 60 days of bedrest (-0.02g/cm2; 95%CI -0.05 to 0.00), the male participants receiving iAG showed no decrease in BMD during bedrest (0.00g/cm2; 95%CI -0.04 to 0.05). The modulation of BMAT was inversely correlated with BMD at the same vertebrae. Recreating an axial force vector mechanically on horizontalized participants prevented BMAT accumulation and demineralization. These findings suggest exploring technological advances to translate these clinical benefits to populations at risk of acute or chronic bone loss.
期刊介绍:
The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.