含咪唑基团的2-氨基呋喃、呋喃[2,3-b]吡啶和呋喃[2,3-d]嘧啶的多组分合成方法。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-07-10 DOI:10.1039/d5ob01230a

Ekaterina S. Uvarova , Anton V. Kutasevich , Tatyana Yu. Koldaeva , Vitaly S. Mityanov

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引用次数: 0

摘要

本文提出了一种合成含咪唑取代基的2-氨基呋喃的方法。该方法是基于2-未取代咪唑n -氧化物、芳基乙二醛和3-酮腈的三组分缩合反应。所提出的方法的优点在于它能够在温和的条件下制备不同的目标产品，而不需要使用柱色谱法。随后对合成的2-氨基呋喃进行修饰，有利于形成呋喃[2,3-b]吡啶和呋喃[2,3-d]嘧啶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A multi-component approach to 2-aminofurans, furo[2,3-b]pyridines, and furo[2,3-d]pyrimidines containing an imidazole moiety

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A multi-component approach to 2-aminofurans, furo[2,3-b]pyridines, and furo[2,3-d]pyrimidines containing an imidazole moiety

A methodology for the synthesis of 2-aminofurans containing an imidazole substituent has been developed. This method is based on a three-component condensation of 2-unsubstituted imidazole N-oxides, arylglyoxals, and 3-ketonitriles. The advantage of the presented method lies in its ability to prepare a diverse set of target products on a gram scale under mild conditions without the use of column chromatography. Subsequent modification of the synthesized 2-aminofurans facilitates the formation of furo[2,3-b]pyridines and furo[2,3-d]pyrimidines.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.