银介导的吡啶芳烃分子间邻三氟甲氧基化反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-08-26 DOI:10.1039/d5ob01162k

Lu Guo, Ruijian Fang, Yun Liu, Zhenbo Zhao, Nuochen Ye, Zhijie Deng, Muhammad Bilal Altaf, Pingping Tang

{"title":"银介导的吡啶芳烃分子间邻三氟甲氧基化反应。","authors":"Lu Guo, Ruijian Fang, Yun Liu, Zhenbo Zhao, Nuochen Ye, Zhijie Deng, Muhammad Bilal Altaf, Pingping Tang","doi":"10.1039/d5ob01162k","DOIUrl":null,"url":null,"abstract":"The direct introduction of a trifluoromethoxy group into aromatic C-H bonds is a highly desirable yet formidable transformation, primarily due to the challenges in controlling regioselectivity. While the intramolecular version of this transformation has been reported, developing an intermolecular variant has remained elusive. We herein describe a directing-group-assisted approach that enables regioselective intermolecular aromatic C-H trifluoromethoxylation. This method offers a direct approach to access aromatic trifluoromethoxy compounds.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Silver-mediated intermolecular ortho-trifluoromethoxylation of pyridyl-arenes.\",\"authors\":\"Lu Guo, Ruijian Fang, Yun Liu, Zhenbo Zhao, Nuochen Ye, Zhijie Deng, Muhammad Bilal Altaf, Pingping Tang\",\"doi\":\"10.1039/d5ob01162k\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The direct introduction of a trifluoromethoxy group into aromatic C-H bonds is a highly desirable yet formidable transformation, primarily due to the challenges in controlling regioselectivity. While the intramolecular version of this transformation has been reported, developing an intermolecular variant has remained elusive. We herein describe a directing-group-assisted approach that enables regioselective intermolecular aromatic C-H trifluoromethoxylation. This method offers a direct approach to access aromatic trifluoromethoxy compounds.\",\"PeriodicalId\":96,\"journal\":{\"name\":\"Organic & Biomolecular Chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic & Biomolecular Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d5ob01162k\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5ob01162k","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

将三氟甲氧基直接引入芳香的C-H键是一种非常理想但艰巨的转化，主要是由于控制区域选择性的挑战。虽然这种转化的分子内版本已被报道，但开发分子间变体仍然难以捉摸。我们在此描述了一种定向基团辅助方法，使区域选择性分子间芳香族C-H三氟甲氧基化。该方法提供了一种直接获取芳香族三氟甲氧基化合物的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Silver-mediated intermolecular ortho-trifluoromethoxylation of pyridyl-arenes.

The direct introduction of a trifluoromethoxy group into aromatic C-H bonds is a highly desirable yet formidable transformation, primarily due to the challenges in controlling regioselectivity. While the intramolecular version of this transformation has been reported, developing an intermolecular variant has remained elusive. We herein describe a directing-group-assisted approach that enables regioselective intermolecular aromatic C-H trifluoromethoxylation. This method offers a direct approach to access aromatic trifluoromethoxy compounds.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.