通过钯催化的多米诺Heck/交叉偶联反应快速构建呋喃连接的双杂环。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-07-10 DOI:10.1039/d5ob01081k

Du Wang , Zhilong Yin , Xueli Feng , Huixuan Zhu , Fan Gao , Jiaxin Li , Jingli Zhang , Ye Yuan

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引用次数: 0

摘要

报道了钯催化的烯系芳基碘化物与β-氯酮的多米诺Heck/交叉偶联反应。该反应通过分子内碳化反应在一次操作中形成一个C-O键和两个C-C键以构建双杂环，然后与β-氯烯酮作为非重氮碳前体进行基于碳的交叉偶联，为合成呋喃连接的二氢苯并呋喃/氧吲哚提供了一种高效的方法，收率高达98%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rapid construction of furan-linked bisheterocycles via a palladium-catalyzed domino Heck/cross-coupling reaction

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Rapid construction of furan-linked bisheterocycles via a palladium-catalyzed domino Heck/cross-coupling reaction

A palladium-catalyzed domino Heck/cross-coupling reaction of alkene-tethered aryl iodides with β-chloroenones is reported. This reaction enables the formation of one C–O bond and two C–C bonds to construct bisheterocycles in a single operation via an intramolecular carbopalladation, followed by a carbene-based cross-coupling with β-chloroenones as a non-diazo carbene precursor, providing an efficient method for synthesizing furan-linked dihydrobenzofurans/oxindoles in yields up to 98%.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.