{"title":"口服中分子量透明质酸（200-600 kDa）可减轻d -半乳糖引起的皮肤老化。","authors":"Shuyu Guo, Botao Wang, Bingyong Mao, Tianmeng Zhang, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Wei Chen and Shumao Cui*, ","doi":"10.1021/acs.biomac.5c00935","DOIUrl":null,"url":null,"abstract":"<p >Hyaluronic acid (HA), a functional food ingredient with multitarget biological activities, shows potential in combating age-related disorders. HA levels in skin cells may serve as potential biomarkers for aging and decrease with age. This study first investigated the antiaging efficacy of oral supplementation with HA with different molecular weights (MWs) (2, 30–50, 80–100, 200–600, and 1000 kDa) in a <span>D</span>-galactose-induced aging mouse model. Comparative analysis revealed that 200–600 kDa HA exhibited superior performance in maintaining skin moisture, elasticity, and antifatigue properties. Concomitantly, it significantly increased the amount of HA in the tissues (serum, eyes, skin, and joints) of aging mice. And, it can significantly regulate the diversity and composition of microbial communities. Further analysis of different HA concentrations (low, medium, and high concentrations) of 200–600 kDa revealed that the medium concentration was most effective in alleviating skin aging. This study presents a novel approach to safety utilizing HA for the alleviation of skin aging.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 9","pages":"6015–6027"},"PeriodicalIF":5.4000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oral Supplementation of Medium-Molecular-Weight Hyaluronic Acid (200–600 kDa) As a Functional Food Ingredient Alleviates D-Galactose-Induced Skin Aging\",\"authors\":\"Shuyu Guo, Botao Wang, Bingyong Mao, Tianmeng Zhang, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Wei Chen and Shumao Cui*, \",\"doi\":\"10.1021/acs.biomac.5c00935\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Hyaluronic acid (HA), a functional food ingredient with multitarget biological activities, shows potential in combating age-related disorders. HA levels in skin cells may serve as potential biomarkers for aging and decrease with age. This study first investigated the antiaging efficacy of oral supplementation with HA with different molecular weights (MWs) (2, 30–50, 80–100, 200–600, and 1000 kDa) in a <span>D</span>-galactose-induced aging mouse model. Comparative analysis revealed that 200–600 kDa HA exhibited superior performance in maintaining skin moisture, elasticity, and antifatigue properties. Concomitantly, it significantly increased the amount of HA in the tissues (serum, eyes, skin, and joints) of aging mice. And, it can significantly regulate the diversity and composition of microbial communities. Further analysis of different HA concentrations (low, medium, and high concentrations) of 200–600 kDa revealed that the medium concentration was most effective in alleviating skin aging. This study presents a novel approach to safety utilizing HA for the alleviation of skin aging.</p>\",\"PeriodicalId\":30,\"journal\":{\"name\":\"Biomacromolecules\",\"volume\":\"26 9\",\"pages\":\"6015–6027\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomacromolecules\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.biomac.5c00935\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomacromolecules","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.biomac.5c00935","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Oral Supplementation of Medium-Molecular-Weight Hyaluronic Acid (200–600 kDa) As a Functional Food Ingredient Alleviates D-Galactose-Induced Skin Aging
Hyaluronic acid (HA), a functional food ingredient with multitarget biological activities, shows potential in combating age-related disorders. HA levels in skin cells may serve as potential biomarkers for aging and decrease with age. This study first investigated the antiaging efficacy of oral supplementation with HA with different molecular weights (MWs) (2, 30–50, 80–100, 200–600, and 1000 kDa) in a D-galactose-induced aging mouse model. Comparative analysis revealed that 200–600 kDa HA exhibited superior performance in maintaining skin moisture, elasticity, and antifatigue properties. Concomitantly, it significantly increased the amount of HA in the tissues (serum, eyes, skin, and joints) of aging mice. And, it can significantly regulate the diversity and composition of microbial communities. Further analysis of different HA concentrations (low, medium, and high concentrations) of 200–600 kDa revealed that the medium concentration was most effective in alleviating skin aging. This study presents a novel approach to safety utilizing HA for the alleviation of skin aging.
期刊介绍：
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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