Wang Yanyu, Liu Jie, Zhou Rong, Dang Liangjun, Gao Ling, Wei Shan, Shang Suhang, Wang Jin, Wang Jingyi, Qu Qiumin, Deng Yongning
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引用次数: 0
摘要
目的腹型肥胖与认知功能障碍之间的关系尚不完全清楚。脂质积累产物（LAP）是一种方便、经济的腹部肥胖指标。在本研究中，我们在一项基于社区的4年前瞻性队列研究中调查了LAP与认知功能障碍之间的关系。方法对来自中国西安村的1349名年龄≥40岁、无认知障碍的参与者进行为期4年的随访。认知障碍的诊断采用三步程序。LAP用腰围和血清甘油三酯水平计算。采用多因素logistic回归分析和交互作用分析评估LAP与认知功能障碍的关系。结果基线时平均年龄55.0±9.3岁，女性816人（60.5%），4年随访中诊断为认知障碍46人（3.4%）。多因素logistic回归分析显示lnLAP与总体人群认知功能障碍无相关性。按性别分层后，女性认知障碍与lnLAP相关（OR = 1.85, 95% CI: 1.058-3.257, P = 0.031），而男性与lnLAP无关（OR = 1.142, 95% CI: 0.503-2.594, P = 0.751）。在女性中，LAP最高四分位数的认知障碍是LAP最低四分位数的4.09倍（OR = 4.098, 95% CI: 1.135 ~ 14.792, P = 0.031）。结论高LAP与女性认知功能障碍相关，而与男性无相关性。这些发现表明，腹部肥胖对认知障碍的影响可能在男性和女性之间有所不同。
Association between lipid accumulation product and cognitive impairment: a community-based 4-year prospective cohort study
Objectives
The relationship between abdominal obesity and cognitive impairment is not fully understood. The lipid accumulation product (LAP) is a convenient and cost-effective indicator for abdominal obesity. In the present study, we investigated the association between the LAP and cognitive impairment in a community-based 4-year prospective cohort study.
Methods
A total of 1349 (≥ 40 years) participants without cognitive impairment from the village of Xi’an, China were followed for 4 years. Cognitive impairment was diagnosed using a three-step protocol. The LAP was calculated using waist circumference and serum triglyceride levels. Multivariate logistic regression analysis and interaction analysis were used to assess the relationship between the LAP and cognitive impairment.
Results
The mean age of the participants at baseline was 55.0 ± 9.3 years, 816(60.5%) were female, and 46 (3.4%) were diagnosed as cognitive impairment during the 4-year follow-up. Multivariate logistic regression analysis revealed that lnLAP was not associated with the cognitive impairment in the total population. After stratification by sex, cognitive impairment was associated with lnLAP (OR = 1.85, 95% CI: 1.058–3.257, P = 0.031) in females but not in males (OR = 1.142, 95% CI: 0.503–2.594, P = 0.751). In the females, cognitive impairment was 4.09-fold greater in the highest LAP quartile than that in the lowest LAP quartile (OR = 4.098, 95% CI: 1.135–14.792, P = 0.031).
Conclusion
High LAP was associated with cognitive impairment in females but not in males. These findings indicate that the effects of abdominal obesity on cognitive impairment may differ between males and females.
期刊介绍：
Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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