DNA解压缩过渡

IF 1.7 4区物理与天体物理 Q3 PHYSICS, CONDENSED MATTER

The European Physical Journal B Pub Date : 2025-09-02 DOI:10.1140/epjb/s10051-025-01028-8

Somendra M. Bhattacharjee

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引用次数: 0

摘要

本文综述了双链DNA的力诱导解压缩转变。它从DNA融化的简史开始，它伴随着分子生物学领域的发展而出现，并与第二次世界大战后物理学的进步并存。早期的DNA熔化理论是基于伊辛模型及其修正，但逐渐转向基于聚合物的模型。力诱导解拉链的想法最早是在1999年提出的，作为一种不需要温度变化就能破坏碱基对的合作机制。本文讨论了解决解压缩转换的不同方面的几个后续发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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DNA unzipping transition

This review focuses on the force-induced unzipping transition of double-stranded DNA. It begins with a brief history of DNA melting, which emerged alongside the growth of the field of molecular biology, juxtaposed with the advancements in physics during the same post-World War II period. The earlier theories of melting of DNA were based on the Ising model and its modifications, but gradually moved toward polymer-based models. The idea of force-induced unzipping was first introduced in 1999 as a cooperative mechanism for breaking base pairs without the need for temperature changes. The paper discusses several subsequent developments addressing different aspects of the unzipping transition.

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