Dr. Van Tuan Trinh, Dr. Sabrina Fischer, Dr. Lei Zhang, Dr. Heiko Geisler, Belen Pardo, Dr. Robert Liefke, Dr. Frank Abendroth, Prof.Dr. Olalla Vázquez
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引用次数: 0
摘要
如图所示，HIF1α-VHL信号通路是一组相互连接的齿轮。我们的可见光肽，PSB-BCB-04，通过四邻氟偶氮苯短链使HIF-1α在常氧条件下有条件稳定，其顺式构象通过破坏EloBC-pVHL相互作用抑制VHL复合物。研究细节由Olalla Vazquez et al.在他们的Communication （e202511183）中报道。封面图片由M. Eugenio Vázquez （@glowsticks.bsky.social）
Outside Front Cover: Conditional Stabilization of the Hypoxia-Inducible Factor HIF1α: Photoswitchable Stapled Peptides Prevent Elongin BC–Mediated Degradation (Angew. Chem. 36/2025)
The image illustrates the HIF1α-VHL signalling pathway as a set of interconnected gears. Our visible-light peptide, PSB-BCB-04, enables conditional stabilization of HIF-1α under normoxia by means of a tetra-ortho-fluoroazobenzene staple, whose cis conformation inhibits the VHL complex by disrupting the EloBC-pVHL interaction. Details of the study are reported by Olalla Vazquez et al. in their Communication (e202511183). Cover art image by M. Eugenio Vázquez (@glowsticks.bsky.social)
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