{"title":"一种用于治疗的新型氧载体","authors":"Benoit Barrou, Elisabeth Leize-Zal, Franck Zal","doi":"10.1002/dta.3847","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>The natural extracellular hemoglobin of the lugworm <i>Arenicola marina</i> (AmHb) has many interesting characteristics: It carries 40 times more oxygen than human hemoglobin; has anti-inflammatory, antibacterial, and antioxidant properties; and is 250 times smaller than a red blood cell. It is nontoxic and nonimmunogenic. It is thus a very promising hemoglobin-based oxygen carrier. AmHb is extracted and purified in GMP conditions to produce a therapeutic molecule, called M101. It is used in various forms (liquid, hydrogel, and lyophilized) to respond to different situations of hypoxia in the healthcare field, such as organ preservation prior to transplantation, wound and burn healing, periodontitis, sickle cell disease, and red blood cell transfusions, particularly in emergency situations. Given these remarkable oxygen transport capacities, M101 could be misused for doping purposes. This article presents current and future developments in this molecule.</p>\n </div>","PeriodicalId":160,"journal":{"name":"Drug Testing and Analysis","volume":"17 9","pages":"1490-1501"},"PeriodicalIF":2.7000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A New Oxygen Carrier for Therapeutic Applications\",\"authors\":\"Benoit Barrou, Elisabeth Leize-Zal, Franck Zal\",\"doi\":\"10.1002/dta.3847\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>The natural extracellular hemoglobin of the lugworm <i>Arenicola marina</i> (AmHb) has many interesting characteristics: It carries 40 times more oxygen than human hemoglobin; has anti-inflammatory, antibacterial, and antioxidant properties; and is 250 times smaller than a red blood cell. It is nontoxic and nonimmunogenic. It is thus a very promising hemoglobin-based oxygen carrier. AmHb is extracted and purified in GMP conditions to produce a therapeutic molecule, called M101. It is used in various forms (liquid, hydrogel, and lyophilized) to respond to different situations of hypoxia in the healthcare field, such as organ preservation prior to transplantation, wound and burn healing, periodontitis, sickle cell disease, and red blood cell transfusions, particularly in emergency situations. Given these remarkable oxygen transport capacities, M101 could be misused for doping purposes. This article presents current and future developments in this molecule.</p>\\n </div>\",\"PeriodicalId\":160,\"journal\":{\"name\":\"Drug Testing and Analysis\",\"volume\":\"17 9\",\"pages\":\"1490-1501\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-01-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Testing and Analysis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3847\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Testing and Analysis","FirstCategoryId":"3","ListUrlMain":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3847","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
The natural extracellular hemoglobin of the lugworm Arenicola marina (AmHb) has many interesting characteristics: It carries 40 times more oxygen than human hemoglobin; has anti-inflammatory, antibacterial, and antioxidant properties; and is 250 times smaller than a red blood cell. It is nontoxic and nonimmunogenic. It is thus a very promising hemoglobin-based oxygen carrier. AmHb is extracted and purified in GMP conditions to produce a therapeutic molecule, called M101. It is used in various forms (liquid, hydrogel, and lyophilized) to respond to different situations of hypoxia in the healthcare field, such as organ preservation prior to transplantation, wound and burn healing, periodontitis, sickle cell disease, and red blood cell transfusions, particularly in emergency situations. Given these remarkable oxygen transport capacities, M101 could be misused for doping purposes. This article presents current and future developments in this molecule.
期刊介绍：
As the incidence of drugs escalates in 21st century living, their detection and analysis have become increasingly important. Sport, the workplace, crime investigation, homeland security, the pharmaceutical industry and the environment are just some of the high profile arenas in which analytical testing has provided an important investigative tool for uncovering the presence of extraneous substances.
In addition to the usual publishing fare of primary research articles, case reports and letters, Drug Testing and Analysis offers a unique combination of; ‘How to’ material such as ‘Tutorials’ and ‘Reviews’, Speculative pieces (‘Commentaries’ and ‘Perspectives'', providing a broader scientific and social context to the aspects of analytical testing), ‘Annual banned substance reviews’ (delivering a critical evaluation of the methods used in the characterization of established and newly outlawed compounds).
Rather than focus on the application of a single technique, Drug Testing and Analysis employs a unique multidisciplinary approach to the field of controversial compound determination. Papers discussing chromatography, mass spectrometry, immunological approaches, 1D/2D gel electrophoresis, to name just a few select methods, are welcomed where their application is related to any of the six key topics listed below.
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