比较臭氧联合透明质酸治疗与单独使用透明质酸缓解膝关节骨关节炎患者疼痛的疗效：一项随机临床试验

IF 3.5 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine Pub Date : 2025-08-25 DOI:10.1016/j.ctim.2025.103238

Ghodrat Akhavanakbari , Maryam Asayeshi , Reza Noktehsanj , Mohammad Reza Aslani

{"title":"比较臭氧联合透明质酸治疗与单独使用透明质酸缓解膝关节骨关节炎患者疼痛的疗效：一项随机临床试验","authors":"Ghodrat Akhavanakbari , Maryam Asayeshi , Reza Noktehsanj , Mohammad Reza Aslani","doi":"10.1016/j.ctim.2025.103238","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA versus a mixture of OZ and HA in alleviating pain for patients diagnosed with OA.</div></div><div><h3>Methods</h3><div>In a double-blind clinical trial, 60 patients diagnosed with OA were randomly divided into two groups: One group was administered four intra-articular (IA) injections of hyaluronic acid (HA) every week (HA group), while the second group received the same frequency of injections but with ozone combined with HA (OZ+HA group). Patients underwent evaluations for pain levels utilizing the Visual Analogue Scale (VAS), assessed their quality of life with support from Health-Related Quality of Life (HRQL) metrics, and analyzed sleep quality using the Pittsburgh Sleep Quality Index (PSQI) at initial assessment and again at 2 weeks, 2 months, and 6 months following the intervention.</div></div><div><h3>Results</h3><div>Results indicated a significant decrease in the VAS-score value for both groups after six months of intervention, with the OZ + HA group experiencing a greater reduction (P < 0.001 for both). The HRQL value changes were significantly more pronounced in the OZ+HA group than in the HA group by the end of the study (P < 0.001). The decrease in the PSQI score in the OZ + HA group following six months of intervention was substantially less compared to the HA group (P < 0.001).</div></div><div><h3>Conclusion</h3><div>The combination of ozone and HA appears to have an enhancing effect on analgesic outcomes, sleep, and quality of life, indicating a need for further research.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"93 ","pages":"Article 103238"},"PeriodicalIF":3.5000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparing the efficacy of combining ozone therapy with hyaluronic acid versus using hyaluronic acid alone for pain relief in patients with knee osteoarthritis: A randomized clinical trial\",\"authors\":\"Ghodrat Akhavanakbari , Maryam Asayeshi , Reza Noktehsanj , Mohammad Reza Aslani\",\"doi\":\"10.1016/j.ctim.2025.103238\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA versus a mixture of OZ and HA in alleviating pain for patients diagnosed with OA.</div></div><div><h3>Methods</h3><div>In a double-blind clinical trial, 60 patients diagnosed with OA were randomly divided into two groups: One group was administered four intra-articular (IA) injections of hyaluronic acid (HA) every week (HA group), while the second group received the same frequency of injections but with ozone combined with HA (OZ+HA group). Patients underwent evaluations for pain levels utilizing the Visual Analogue Scale (VAS), assessed their quality of life with support from Health-Related Quality of Life (HRQL) metrics, and analyzed sleep quality using the Pittsburgh Sleep Quality Index (PSQI) at initial assessment and again at 2 weeks, 2 months, and 6 months following the intervention.</div></div><div><h3>Results</h3><div>Results indicated a significant decrease in the VAS-score value for both groups after six months of intervention, with the OZ + HA group experiencing a greater reduction (P < 0.001 for both). The HRQL value changes were significantly more pronounced in the OZ+HA group than in the HA group by the end of the study (P < 0.001). The decrease in the PSQI score in the OZ + HA group following six months of intervention was substantially less compared to the HA group (P < 0.001).</div></div><div><h3>Conclusion</h3><div>The combination of ozone and HA appears to have an enhancing effect on analgesic outcomes, sleep, and quality of life, indicating a need for further research.</div></div>\",\"PeriodicalId\":10545,\"journal\":{\"name\":\"Complementary therapies in medicine\",\"volume\":\"93 \",\"pages\":\"Article 103238\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Complementary therapies in medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S096522992500113X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Complementary therapies in medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S096522992500113X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

臭氧（OZ）和透明质酸（HA）治疗骨关节炎的应用越来越受到关注。这项随机试验旨在评估透明质酸与混合透明质酸在缓解OA患者疼痛方面的有效性。方法采用双盲临床试验，将60例OA患者随机分为两组：一组患者每周给予4次关节内注射透明质酸（HA）（HA组），另一组患者给予相同注射频率但臭氧联合HA （OZ+HA组）。使用视觉模拟量表（VAS）对患者进行疼痛水平评估，在健康相关生活质量（HRQL）指标的支持下评估他们的生活质量，并在最初评估时使用匹兹堡睡眠质量指数（PSQI）分析睡眠质量，并在干预后2周、2个月和6个月再次进行评估。结果表明，干预6个月后，两组vas评分值均显著下降，其中OZ + HA组下降幅度更大（P <； 0.001）。研究结束时，OZ+HA组的HRQL值变化明显比HA组更明显（P <； 0.001）。干预六个月后，与HA组相比，OZ + HA组PSQI评分的下降幅度要小得多（P <； 0.001）。结论臭氧与透明质酸联用对镇痛效果、睡眠和生活质量有增强作用，有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Comparing the efficacy of combining ozone therapy with hyaluronic acid versus using hyaluronic acid alone for pain relief in patients with knee osteoarthritis: A randomized clinical trial

Background

There is growing interest in the therapeutic application of ozone (OZ) and hyaluronic acid (HA) for individuals suffering from osteoarthritis. This randomized trial aimed to assess the effectiveness of HA versus a mixture of OZ and HA in alleviating pain for patients diagnosed with OA.

Methods

In a double-blind clinical trial, 60 patients diagnosed with OA were randomly divided into two groups: One group was administered four intra-articular (IA) injections of hyaluronic acid (HA) every week (HA group), while the second group received the same frequency of injections but with ozone combined with HA (OZ+HA group). Patients underwent evaluations for pain levels utilizing the Visual Analogue Scale (VAS), assessed their quality of life with support from Health-Related Quality of Life (HRQL) metrics, and analyzed sleep quality using the Pittsburgh Sleep Quality Index (PSQI) at initial assessment and again at 2 weeks, 2 months, and 6 months following the intervention.

Results

Results indicated a significant decrease in the VAS-score value for both groups after six months of intervention, with the OZ + HA group experiencing a greater reduction (P < 0.001 for both). The HRQL value changes were significantly more pronounced in the OZ+HA group than in the HA group by the end of the study (P < 0.001). The decrease in the PSQI score in the OZ + HA group following six months of intervention was substantially less compared to the HA group (P < 0.001).

Conclusion

The combination of ozone and HA appears to have an enhancing effect on analgesic outcomes, sleep, and quality of life, indicating a need for further research.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Complementary therapies in medicine 医学-全科医学与补充医学

CiteScore

8.60

自引率

2.80%

发文量

101

审稿时长

112 days

期刊介绍： Complementary Therapies in Medicine is an international, peer-reviewed journal that has considerable appeal to anyone who seeks objective and critical information on complementary therapies or who wishes to deepen their understanding of these approaches. It will be of particular interest to healthcare practitioners including family practitioners, complementary therapists, nurses, and physiotherapists; to academics including social scientists and CAM researchers; to healthcare managers; and to patients. Complementary Therapies in Medicine aims to publish valid, relevant and rigorous research and serious discussion articles with the main purpose of improving healthcare.