{"title":"单细胞质谱法同位素标记分析","authors":"Anh Hai Vu, Sarah Ellen O'Connor, Lorenzo Caputi","doi":"10.1039/d5an00657k","DOIUrl":null,"url":null,"abstract":"In this proof-of-concept work, we applied single-cell mass spectrometry to track the incorporation of an isotopically labelled precursor into plant specialized metabolites. The application of stable-isotope labelling to single cell systems could provide a unique window into the dynamics of synthesis and intercellular transport of structurally complex metabolites.","PeriodicalId":63,"journal":{"name":"Analyst","volume":"23 1","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Isotopic Labelling Analysis using Single Cell Mass Spectrometry\",\"authors\":\"Anh Hai Vu, Sarah Ellen O'Connor, Lorenzo Caputi\",\"doi\":\"10.1039/d5an00657k\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this proof-of-concept work, we applied single-cell mass spectrometry to track the incorporation of an isotopically labelled precursor into plant specialized metabolites. The application of stable-isotope labelling to single cell systems could provide a unique window into the dynamics of synthesis and intercellular transport of structurally complex metabolites.\",\"PeriodicalId\":63,\"journal\":{\"name\":\"Analyst\",\"volume\":\"23 1\",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analyst\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d5an00657k\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analyst","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5an00657k","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Isotopic Labelling Analysis using Single Cell Mass Spectrometry
In this proof-of-concept work, we applied single-cell mass spectrometry to track the incorporation of an isotopically labelled precursor into plant specialized metabolites. The application of stable-isotope labelling to single cell systems could provide a unique window into the dynamics of synthesis and intercellular transport of structurally complex metabolites.