快速发作性肌张力障碍-帕金森病灰质体积的结构改变

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2025-09-01 DOI:10.1002/mds.30320

Ihtsham U. Haq, Kristina Simonyan, Eleonora Napoli, Laurie J. Ozelius, Beverly M. Snively, Christopher T. Whitlow, Kathleen J. Sweadner, Allison Brashear

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引用次数: 0

摘要

之前，我们发现ATP1A3变异患者丘脑血流量减少。目的：本研究评估快速发作性肌张力障碍-帕金森病（RDP）患者与对照组和两种表型重叠运动障碍患者的灰质结构。方法对17例RDP患者、20例孤立性肌张力障碍患者、20例帕金森病（PD）患者和20例对照组的全脑灰质体积（GMV）异常进行结构磁共振成像检查。结果RDP组左前额叶皮质体积均增加。与对照组相比，RDP患者右侧颞下叶皮层和梭状回的双侧体积增加，与肌张力障碍相比，下顶叶皮层和丘脑的GMV变化，与PD相比，小脑的GMV变化。RDP持续时间与GMV在右侧前额叶皮层和双侧尾状核呈负相关。结论RDP的结构改变涉及感觉运动脑区和执行脑区。©2025作者。Wiley期刊有限责任公司代表国际帕金森和运动障碍学会出版的《运动障碍》。

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Structural Alterations in the Gray Matter Volume in Rapid‐Onset Dystonia‐Parkinsonism

BackgroundPreviously, we identified decreased thalamic blood flow in patients with ATP1A3 variants.ObjectiveThis study evaluated structural gray matter organization in rapid‐onset dystonia‐parkinsonism (RDP) patients compared with controls and two phenotypically overlapping movement disorders.MethodsStructural magnetic resonance imaging data were examined for whole‐brain gray matter volume (GMV) abnormalities in 17 RDP patients, 20 isolated dystonia patients, 20 Parkinson's disease (PD) patients, and 20 controls.ResultsLeft prefrontal cortical volume was increased in the RDP group in all comparisons. RDP patients showed additional bilateral volumetric increases in the right inferior temporal cortex and fusiform gyrus compared with controls, GMV changes in the inferior parietal cortex and thalamus compared with dystonia, and in the cerebellum compared with PD. Negative correlations between RDP duration and GMV were found in the right prefrontal cortex and bilateral caudate nucleus.ConclusionOur data suggest that structural alterations in RDP involve sensorimotor and executive brain regions. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.