{"title":"混合漫反射光谱（HDRS-ISO 23698）方法在ALT-SPF联盟验证研究中用于防晒霜防护评估的性能","authors":"Eduardo Ruvolo, Curtis Cole, Mathias Rohr, Jay Silverman, Omid Yousefian, Jan Batzer, Nele Lange, Rita Touti, Florence Pouradier, Luciano Nogueira, Bertrand Colson","doi":"10.1111/ics.13089","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Alternative methods to the traditional in vivo sun protection factor (SPF) test are desirable for many reasons. Hybrid DRS (HDRS) (combining in vitro transmission spectroscopy with in vivo DRS spectroscopy) was used in an extensive ring study to characterize its ability to estimate topical sunscreen protection and compared with the currently recognized ‘gold standard’ human in vivo Sun Protection Factor (SPF-ISO24444), Ultraviolet-A Protection Factor (UVA-PF), and Critical Wavelength (CW) (ISO 24443) Reference Methods sponsored by the Alternative SPF Consortium.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Diffuse reflectance spectroscopy (DRS) of skin provides a rapid, convenient non-invasive tool to evaluate skin properties as well as the optical properties of materials applied to the skin, such as sunscreens. DRS methodology combines in vivo measurement of sunscreen absorbance on skin in the Ultraviolet A (UVA) region with full spectrum in vitro spectrophotometric absorbance scans to provide a full spectrum measurement of the protection of sunscreen on skin.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Results from testing with both monochromatic and polychromatic HDRS devices provided strong correlation of SPF, UVA-PF and Critical Wavelength results with their corresponding ‘gold standard’ counterpart methods in Study 1 for bias (or ‘accuracy’), however with more variability within certain product types. Further training of personnel conducting the HDRS studies was conducted prior to a second follow-up ring study using many of the same blinded samples from Study 1 in addition to Reference Standard sunscreens.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The results showed marked improvement in the variability to a level equivalent to the reference methods while maintaining accuracy of the estimates of the protection values. Virtually all estimates were within the Prediction Intervals (PI) of the reference methods for the second study. HDRS offers the ability to accurately assess sunscreen performance for SPF, UVA-PF as well as CW without invasive damage to test subjects and offers in the future the opportunity to assess water resistance performance.</p>\n </section>\n </div>","PeriodicalId":13936,"journal":{"name":"International Journal of Cosmetic Science","volume":"47 S1","pages":"53-77"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ics.13089","citationCount":"0","resultStr":"{\"title\":\"Performance of hybrid diffuse reflectance spectroscopy (HDRS-ISO 23698) methodology for assessment of sunscreen protection in the ALT-SPF Consortium validation study\",\"authors\":\"Eduardo Ruvolo, Curtis Cole, Mathias Rohr, Jay Silverman, Omid Yousefian, Jan Batzer, Nele Lange, Rita Touti, Florence Pouradier, Luciano Nogueira, Bertrand Colson\",\"doi\":\"10.1111/ics.13089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Alternative methods to the traditional in vivo sun protection factor (SPF) test are desirable for many reasons. Hybrid DRS (HDRS) (combining in vitro transmission spectroscopy with in vivo DRS spectroscopy) was used in an extensive ring study to characterize its ability to estimate topical sunscreen protection and compared with the currently recognized ‘gold standard’ human in vivo Sun Protection Factor (SPF-ISO24444), Ultraviolet-A Protection Factor (UVA-PF), and Critical Wavelength (CW) (ISO 24443) Reference Methods sponsored by the Alternative SPF Consortium.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Diffuse reflectance spectroscopy (DRS) of skin provides a rapid, convenient non-invasive tool to evaluate skin properties as well as the optical properties of materials applied to the skin, such as sunscreens. DRS methodology combines in vivo measurement of sunscreen absorbance on skin in the Ultraviolet A (UVA) region with full spectrum in vitro spectrophotometric absorbance scans to provide a full spectrum measurement of the protection of sunscreen on skin.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Results from testing with both monochromatic and polychromatic HDRS devices provided strong correlation of SPF, UVA-PF and Critical Wavelength results with their corresponding ‘gold standard’ counterpart methods in Study 1 for bias (or ‘accuracy’), however with more variability within certain product types. Further training of personnel conducting the HDRS studies was conducted prior to a second follow-up ring study using many of the same blinded samples from Study 1 in addition to Reference Standard sunscreens.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>The results showed marked improvement in the variability to a level equivalent to the reference methods while maintaining accuracy of the estimates of the protection values. Virtually all estimates were within the Prediction Intervals (PI) of the reference methods for the second study. HDRS offers the ability to accurately assess sunscreen performance for SPF, UVA-PF as well as CW without invasive damage to test subjects and offers in the future the opportunity to assess water resistance performance.</p>\\n </section>\\n </div>\",\"PeriodicalId\":13936,\"journal\":{\"name\":\"International Journal of Cosmetic Science\",\"volume\":\"47 S1\",\"pages\":\"53-77\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ics.13089\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Cosmetic Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ics.13089\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Cosmetic Science","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ics.13089","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Performance of hybrid diffuse reflectance spectroscopy (HDRS-ISO 23698) methodology for assessment of sunscreen protection in the ALT-SPF Consortium validation study
Objective
Alternative methods to the traditional in vivo sun protection factor (SPF) test are desirable for many reasons. Hybrid DRS (HDRS) (combining in vitro transmission spectroscopy with in vivo DRS spectroscopy) was used in an extensive ring study to characterize its ability to estimate topical sunscreen protection and compared with the currently recognized ‘gold standard’ human in vivo Sun Protection Factor (SPF-ISO24444), Ultraviolet-A Protection Factor (UVA-PF), and Critical Wavelength (CW) (ISO 24443) Reference Methods sponsored by the Alternative SPF Consortium.
Methods
Diffuse reflectance spectroscopy (DRS) of skin provides a rapid, convenient non-invasive tool to evaluate skin properties as well as the optical properties of materials applied to the skin, such as sunscreens. DRS methodology combines in vivo measurement of sunscreen absorbance on skin in the Ultraviolet A (UVA) region with full spectrum in vitro spectrophotometric absorbance scans to provide a full spectrum measurement of the protection of sunscreen on skin.
Results
Results from testing with both monochromatic and polychromatic HDRS devices provided strong correlation of SPF, UVA-PF and Critical Wavelength results with their corresponding ‘gold standard’ counterpart methods in Study 1 for bias (or ‘accuracy’), however with more variability within certain product types. Further training of personnel conducting the HDRS studies was conducted prior to a second follow-up ring study using many of the same blinded samples from Study 1 in addition to Reference Standard sunscreens.
Conclusions
The results showed marked improvement in the variability to a level equivalent to the reference methods while maintaining accuracy of the estimates of the protection values. Virtually all estimates were within the Prediction Intervals (PI) of the reference methods for the second study. HDRS offers the ability to accurately assess sunscreen performance for SPF, UVA-PF as well as CW without invasive damage to test subjects and offers in the future the opportunity to assess water resistance performance.
期刊介绍：
The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes.
The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
