{"title":"基于非连续脱湿的表面工程合成具有可调水分散性的单分散聚二甲基硅氧烷微粒","authors":"Chan Woo Park, Yunkyeong Cho, Jae Jung Kim","doi":"10.1007/s11814-025-00502-4","DOIUrl":null,"url":null,"abstract":"<div><p>Polydimethylsiloxane (PDMS) microparticles exhibit significant potential for biomedical applications owing to their biocompatibility, chemical inertness, transparency, and ease of soft lithography-based fabrication. However, their high viscosity and hydrophobicity make it difficult to use them in the form of particles in aqueous environments. In this study, we present a novel and efficient methodology for fabricating uniform PDMS microparticles using a discontinuous dewetting (DD) technique. Our approach employs a polyethylene glycol diacrylate mold coated with a superhydrophobic layer, enabling DD over a broad viscosity range and achieving highly monodisperse particle production. To utilize them in an aqueous solution, we implemented two surface modification strategies: a bovine serum albumin (BSA) treatment, and the formation of “hydrogel skin”. Such strategies enhance their water wettability and the particle’s dispersion in an aqueous solution. Our findings demonstrate the successful fabrication of monodisperse PDMS microparticles with diameters ranging from 200 to 1000 μm, which were well dispersed in organic or aqueous solutions. Our research would suggest a new strategy for how to use PDMS in bioengineering. We anticipate that our PDMS microparticles offer significant potential in diagnostic, chemotaxis, and therapeutic applications.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 11","pages":"2777 - 2786"},"PeriodicalIF":3.2000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Discontinuous Dewetting-Based Synthesis of Monodisperse Polydimethylsiloxane Microparticles with Tunable Aqueous Dispersibility via Surface Engineering\",\"authors\":\"Chan Woo Park, Yunkyeong Cho, Jae Jung Kim\",\"doi\":\"10.1007/s11814-025-00502-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Polydimethylsiloxane (PDMS) microparticles exhibit significant potential for biomedical applications owing to their biocompatibility, chemical inertness, transparency, and ease of soft lithography-based fabrication. However, their high viscosity and hydrophobicity make it difficult to use them in the form of particles in aqueous environments. In this study, we present a novel and efficient methodology for fabricating uniform PDMS microparticles using a discontinuous dewetting (DD) technique. Our approach employs a polyethylene glycol diacrylate mold coated with a superhydrophobic layer, enabling DD over a broad viscosity range and achieving highly monodisperse particle production. To utilize them in an aqueous solution, we implemented two surface modification strategies: a bovine serum albumin (BSA) treatment, and the formation of “hydrogel skin”. Such strategies enhance their water wettability and the particle’s dispersion in an aqueous solution. Our findings demonstrate the successful fabrication of monodisperse PDMS microparticles with diameters ranging from 200 to 1000 μm, which were well dispersed in organic or aqueous solutions. Our research would suggest a new strategy for how to use PDMS in bioengineering. We anticipate that our PDMS microparticles offer significant potential in diagnostic, chemotaxis, and therapeutic applications.</p></div>\",\"PeriodicalId\":684,\"journal\":{\"name\":\"Korean Journal of Chemical Engineering\",\"volume\":\"42 11\",\"pages\":\"2777 - 2786\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Korean Journal of Chemical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11814-025-00502-4\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Chemical Engineering","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s11814-025-00502-4","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Discontinuous Dewetting-Based Synthesis of Monodisperse Polydimethylsiloxane Microparticles with Tunable Aqueous Dispersibility via Surface Engineering
Polydimethylsiloxane (PDMS) microparticles exhibit significant potential for biomedical applications owing to their biocompatibility, chemical inertness, transparency, and ease of soft lithography-based fabrication. However, their high viscosity and hydrophobicity make it difficult to use them in the form of particles in aqueous environments. In this study, we present a novel and efficient methodology for fabricating uniform PDMS microparticles using a discontinuous dewetting (DD) technique. Our approach employs a polyethylene glycol diacrylate mold coated with a superhydrophobic layer, enabling DD over a broad viscosity range and achieving highly monodisperse particle production. To utilize them in an aqueous solution, we implemented two surface modification strategies: a bovine serum albumin (BSA) treatment, and the formation of “hydrogel skin”. Such strategies enhance their water wettability and the particle’s dispersion in an aqueous solution. Our findings demonstrate the successful fabrication of monodisperse PDMS microparticles with diameters ranging from 200 to 1000 μm, which were well dispersed in organic or aqueous solutions. Our research would suggest a new strategy for how to use PDMS in bioengineering. We anticipate that our PDMS microparticles offer significant potential in diagnostic, chemotaxis, and therapeutic applications.
期刊介绍:
The Korean Journal of Chemical Engineering provides a global forum for the dissemination of research in chemical engineering. The Journal publishes significant research results obtained in the Asia-Pacific region, and simultaneously introduces recent technical progress made in other areas of the world to this region. Submitted research papers must be of potential industrial significance and specifically concerned with chemical engineering. The editors will give preference to papers having a clearly stated practical scope and applicability in the areas of chemical engineering, and to those where new theoretical concepts are supported by new experimental details. The Journal also regularly publishes featured reviews on emerging and industrially important subjects of chemical engineering as well as selected papers presented at international conferences on the subjects.