基于非连续脱湿的表面工程合成具有可调水分散性的单分散聚二甲基硅氧烷微粒

IF 3.2 4区 工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY
Chan Woo Park, Yunkyeong Cho, Jae Jung Kim
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引用次数: 0

摘要

聚二甲基硅氧烷(PDMS)微粒由于其生物相容性、化学惰性、透明度和易于基于软光刻的制造而在生物医学应用中表现出巨大的潜力。然而,它们的高粘度和疏水性使得它们难以在水环境中以颗粒的形式使用。在这项研究中,我们提出了一种新颖而有效的方法,利用不连续脱湿(DD)技术来制造均匀的PDMS微粒。我们的方法采用涂有超疏水层的聚乙二醇二丙烯酸酯模具,使DD能够在很宽的粘度范围内生产,并实现高度单分散的颗粒生产。为了在水溶液中利用它们,我们实施了两种表面修饰策略:牛血清白蛋白(BSA)处理和“水凝胶皮肤”的形成。这种策略增强了它们的水润湿性和颗粒在水溶液中的分散。我们的发现证明了单分散PDMS微粒子的成功制备,其直径范围为200至1000 μm,在有机或水溶液中分散良好。本研究为PDMS在生物工程中的应用提供了新的思路。我们预计我们的PDMS微粒在诊断、趋化和治疗应用方面具有巨大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Discontinuous Dewetting-Based Synthesis of Monodisperse Polydimethylsiloxane Microparticles with Tunable Aqueous Dispersibility via Surface Engineering

Discontinuous Dewetting-Based Synthesis of Monodisperse Polydimethylsiloxane Microparticles with Tunable Aqueous Dispersibility via Surface Engineering

Discontinuous Dewetting-Based Synthesis of Monodisperse Polydimethylsiloxane Microparticles with Tunable Aqueous Dispersibility via Surface Engineering

Polydimethylsiloxane (PDMS) microparticles exhibit significant potential for biomedical applications owing to their biocompatibility, chemical inertness, transparency, and ease of soft lithography-based fabrication. However, their high viscosity and hydrophobicity make it difficult to use them in the form of particles in aqueous environments. In this study, we present a novel and efficient methodology for fabricating uniform PDMS microparticles using a discontinuous dewetting (DD) technique. Our approach employs a polyethylene glycol diacrylate mold coated with a superhydrophobic layer, enabling DD over a broad viscosity range and achieving highly monodisperse particle production. To utilize them in an aqueous solution, we implemented two surface modification strategies: a bovine serum albumin (BSA) treatment, and the formation of “hydrogel skin”. Such strategies enhance their water wettability and the particle’s dispersion in an aqueous solution. Our findings demonstrate the successful fabrication of monodisperse PDMS microparticles with diameters ranging from 200 to 1000 μm, which were well dispersed in organic or aqueous solutions. Our research would suggest a new strategy for how to use PDMS in bioengineering. We anticipate that our PDMS microparticles offer significant potential in diagnostic, chemotaxis, and therapeutic applications.

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来源期刊
Korean Journal of Chemical Engineering
Korean Journal of Chemical Engineering 工程技术-工程:化工
CiteScore
4.60
自引率
11.10%
发文量
310
审稿时长
4.7 months
期刊介绍: The Korean Journal of Chemical Engineering provides a global forum for the dissemination of research in chemical engineering. The Journal publishes significant research results obtained in the Asia-Pacific region, and simultaneously introduces recent technical progress made in other areas of the world to this region. Submitted research papers must be of potential industrial significance and specifically concerned with chemical engineering. The editors will give preference to papers having a clearly stated practical scope and applicability in the areas of chemical engineering, and to those where new theoretical concepts are supported by new experimental details. The Journal also regularly publishes featured reviews on emerging and industrially important subjects of chemical engineering as well as selected papers presented at international conferences on the subjects.
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